Zebrafish models for studying cognitive enhancers

Tatiana O. Kolesnikova; Konstantin A. Demin; Fabiano V. Costa; Murilo S. de Abreu; Allan V. Kalueff

doi:10.1016/j.neubiorev.2024.105797

Zebrafish models for studying cognitive enhancers

Tatiana O. Kolesnikova, Konstantin A. Demin, Fabiano V. Costa, Murilo S. de Abreu^*, Allan V. Kalueff^*

^*Corresponding author for this work

Department of Biosciences and Bioinformatics

Research output: Contribution to journal › Review article › peer-review

Abstract

Cognitive decline is commonly seen both in normal aging and in neurodegenerative and neuropsychiatric diseases. Various experimental animal models represent a valuable tool to study brain cognitive processes and their deficits. Equally important is the search for novel drugs to treat cognitive deficits and improve cognitions. Complementing rodent and clinical findings, studies utilizing zebrafish (Danio rerio) are rapidly gaining popularity in translational cognitive research and neuroactive drug screening. Here, we discuss the value of zebrafish models and assays for screening nootropic (cognitive enhancer) drugs and the discovery of novel nootropics. We also discuss the existing challenges, and outline future directions of research in this field.

Original language	English
Article number	105797
Journal	Neuroscience and Biobehavioral Reviews
Volume	164
DOIs	https://doi.org/10.1016/j.neubiorev.2024.105797
Publication status	Published - Aug 2024

Keywords

Cognition
Cognitive enhancers
Neurodegenerative disorders
Nootropics
Zebrafish

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10.1016/j.neubiorev.2024.105797

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title = "Zebrafish models for studying cognitive enhancers",

abstract = "Cognitive decline is commonly seen both in normal aging and in neurodegenerative and neuropsychiatric diseases. Various experimental animal models represent a valuable tool to study brain cognitive processes and their deficits. Equally important is the search for novel drugs to treat cognitive deficits and improve cognitions. Complementing rodent and clinical findings, studies utilizing zebrafish (Danio rerio) are rapidly gaining popularity in translational cognitive research and neuroactive drug screening. Here, we discuss the value of zebrafish models and assays for screening nootropic (cognitive enhancer) drugs and the discovery of novel nootropics. We also discuss the existing challenges, and outline future directions of research in this field.",

keywords = "Cognition, Cognitive enhancers, Neurodegenerative disorders, Nootropics, Zebrafish",

author = "Kolesnikova, {Tatiana O.} and Demin, {Konstantin A.} and Costa, {Fabiano V.} and {de Abreu}, {Murilo S.} and Kalueff, {Allan V.}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = aug,

doi = "10.1016/j.neubiorev.2024.105797",

language = "English",

volume = "164",

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T1 - Zebrafish models for studying cognitive enhancers

AU - Kolesnikova, Tatiana O.

AU - Demin, Konstantin A.

AU - Costa, Fabiano V.

AU - de Abreu, Murilo S.

AU - Kalueff, Allan V.

PY - 2024/8

Y1 - 2024/8

N2 - Cognitive decline is commonly seen both in normal aging and in neurodegenerative and neuropsychiatric diseases. Various experimental animal models represent a valuable tool to study brain cognitive processes and their deficits. Equally important is the search for novel drugs to treat cognitive deficits and improve cognitions. Complementing rodent and clinical findings, studies utilizing zebrafish (Danio rerio) are rapidly gaining popularity in translational cognitive research and neuroactive drug screening. Here, we discuss the value of zebrafish models and assays for screening nootropic (cognitive enhancer) drugs and the discovery of novel nootropics. We also discuss the existing challenges, and outline future directions of research in this field.

AB - Cognitive decline is commonly seen both in normal aging and in neurodegenerative and neuropsychiatric diseases. Various experimental animal models represent a valuable tool to study brain cognitive processes and their deficits. Equally important is the search for novel drugs to treat cognitive deficits and improve cognitions. Complementing rodent and clinical findings, studies utilizing zebrafish (Danio rerio) are rapidly gaining popularity in translational cognitive research and neuroactive drug screening. Here, we discuss the value of zebrafish models and assays for screening nootropic (cognitive enhancer) drugs and the discovery of novel nootropics. We also discuss the existing challenges, and outline future directions of research in this field.

KW - Cognition

KW - Cognitive enhancers

KW - Neurodegenerative disorders

KW - Nootropics

KW - Zebrafish

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DO - 10.1016/j.neubiorev.2024.105797

M3 - Review article

C2 - 38971515

AN - SCOPUS:85199035737

SN - 0149-7634

VL - 164

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

M1 - 105797

ER -

Zebrafish models for studying cognitive enhancers

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Keywords

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