X-ray-induced nanoparticle-based photodynamic therapy of cancer

Xiaoju Zou; Mingzhen Yao; Lun Ma; Marius Hossu; Xiumei Han; Petras Juzenas; Wei Chen

doi:10.2217/nnm.13.198

X-ray-induced nanoparticle-based photodynamic therapy of cancer

Xiaoju Zou, Mingzhen Yao, Lun Ma, Marius Hossu, Xiumei Han, Petras Juzenas, Wei Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

175 Citations (Scopus)

Abstract

Aim: In this study, Ce³⁺-doped lanthanum(III) fluoride (LaF₃:Ce³⁺) nanoparticles were synthesized by a wet-chemistry method in dimethyl sulfoxide (DMSO) and their application as an intracellular light source for photodynamic activation was demonstrated.

Materials & methods: The LaF₃:Ce³⁺/DMSO nanoparticles have a strong green emission with a peak at approximately 520 nm, which is effectively overlapped with the absorption of protoporphyrin IX (PPIX). The nanoparticles were encapsulated into poly(D,L-lactide-co-glycolide (PLGA) microspheres along with PPIX. Upon irradiation with x-rays (90 kV), energy transfer from the LaF₃:Ce³⁺/DMSO nanoparticles to PPIX occurs and singlet oxygen is generated for cancer cell damage.

Results: The LaF₃:Ce³⁺/DMSO/PLGA or LaF₃:Ce³⁺/DMSO/PPIX/PLGA microspheres alone caused only sublethal cytotoxicity to the cancer cells. Upon x-ray irradiation, the LaF₃:Ce³⁺/DMSO/PPIX/PLGA microspheres induced oxidative stress, mitochondrial damage and DNA fragmentation on prostate cancer cells (PC3).

Discussion: The results indicate that x-rays can activate LaF₃:Ce³⁺ and PPIX nanocomposites, which can be a novel method for cancer destruction.

Original language	English
Pages (from-to)	2339-2351
Number of pages	13
Journal	Nanomedicine
Volume	9
Issue number	15
DOIs	https://doi.org/10.2217/nnm.13.198
Publication status	Published - 1 Oct 2014
Externally published	Yes

Keywords

LaF3:Ce3+
cancer
energy transfer
luminescence
nanoparticle
photodynamic therapy
photosensitizer
prostate cancer
singlet oxygen
treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "X-ray-induced nanoparticle-based photodynamic therapy of cancer",

abstract = "Aim: In this study, Ce3+-doped lanthanum(III) fluoride (LaF3:Ce3+) nanoparticles were synthesized by a wet-chemistry method in dimethyl sulfoxide (DMSO) and their application as an intracellular light source for photodynamic activation was demonstrated.Materials & methods: The LaF3:Ce3+/DMSO nanoparticles have a strong green emission with a peak at approximately 520 nm, which is effectively overlapped with the absorption of protoporphyrin IX (PPIX). The nanoparticles were encapsulated into poly(D,L-lactide-co-glycolide (PLGA) microspheres along with PPIX. Upon irradiation with x-rays (90 kV), energy transfer from the LaF3:Ce3+/DMSO nanoparticles to PPIX occurs and singlet oxygen is generated for cancer cell damage.Results: The LaF3:Ce3+/DMSO/PLGA or LaF3:Ce3+/DMSO/PPIX/PLGA microspheres alone caused only sublethal cytotoxicity to the cancer cells. Upon x-ray irradiation, the LaF3:Ce3+/DMSO/PPIX/PLGA microspheres induced oxidative stress, mitochondrial damage and DNA fragmentation on prostate cancer cells (PC3).Discussion: The results indicate that x-rays can activate LaF3:Ce3+ and PPIX nanocomposites, which can be a novel method for cancer destruction.",

keywords = "LaF3:Ce3+, cancer, energy transfer, luminescence, nanoparticle, photodynamic therapy, photosensitizer, prostate cancer, singlet oxygen, treatment",

author = "Xiaoju Zou and Mingzhen Yao and Lun Ma and Marius Hossu and Xiumei Han and Petras Juzenas and Wei Chen",

note = "Publisher Copyright: {\textcopyright} 2014 Future Medicine Ltd.",

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doi = "10.2217/nnm.13.198",

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T1 - X-ray-induced nanoparticle-based photodynamic therapy of cancer

AU - Zou, Xiaoju

AU - Yao, Mingzhen

AU - Ma, Lun

AU - Hossu, Marius

AU - Han, Xiumei

AU - Juzenas, Petras

AU - Chen, Wei

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Aim: In this study, Ce3+-doped lanthanum(III) fluoride (LaF3:Ce3+) nanoparticles were synthesized by a wet-chemistry method in dimethyl sulfoxide (DMSO) and their application as an intracellular light source for photodynamic activation was demonstrated.Materials & methods: The LaF3:Ce3+/DMSO nanoparticles have a strong green emission with a peak at approximately 520 nm, which is effectively overlapped with the absorption of protoporphyrin IX (PPIX). The nanoparticles were encapsulated into poly(D,L-lactide-co-glycolide (PLGA) microspheres along with PPIX. Upon irradiation with x-rays (90 kV), energy transfer from the LaF3:Ce3+/DMSO nanoparticles to PPIX occurs and singlet oxygen is generated for cancer cell damage.Results: The LaF3:Ce3+/DMSO/PLGA or LaF3:Ce3+/DMSO/PPIX/PLGA microspheres alone caused only sublethal cytotoxicity to the cancer cells. Upon x-ray irradiation, the LaF3:Ce3+/DMSO/PPIX/PLGA microspheres induced oxidative stress, mitochondrial damage and DNA fragmentation on prostate cancer cells (PC3).Discussion: The results indicate that x-rays can activate LaF3:Ce3+ and PPIX nanocomposites, which can be a novel method for cancer destruction.

AB - Aim: In this study, Ce3+-doped lanthanum(III) fluoride (LaF3:Ce3+) nanoparticles were synthesized by a wet-chemistry method in dimethyl sulfoxide (DMSO) and their application as an intracellular light source for photodynamic activation was demonstrated.Materials & methods: The LaF3:Ce3+/DMSO nanoparticles have a strong green emission with a peak at approximately 520 nm, which is effectively overlapped with the absorption of protoporphyrin IX (PPIX). The nanoparticles were encapsulated into poly(D,L-lactide-co-glycolide (PLGA) microspheres along with PPIX. Upon irradiation with x-rays (90 kV), energy transfer from the LaF3:Ce3+/DMSO nanoparticles to PPIX occurs and singlet oxygen is generated for cancer cell damage.Results: The LaF3:Ce3+/DMSO/PLGA or LaF3:Ce3+/DMSO/PPIX/PLGA microspheres alone caused only sublethal cytotoxicity to the cancer cells. Upon x-ray irradiation, the LaF3:Ce3+/DMSO/PPIX/PLGA microspheres induced oxidative stress, mitochondrial damage and DNA fragmentation on prostate cancer cells (PC3).Discussion: The results indicate that x-rays can activate LaF3:Ce3+ and PPIX nanocomposites, which can be a novel method for cancer destruction.

KW - LaF3:Ce3+

KW - cancer

KW - energy transfer

KW - luminescence

KW - nanoparticle

KW - photodynamic therapy

KW - photosensitizer

KW - prostate cancer

KW - singlet oxygen

KW - treatment

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JO - Nanomedicine

JF - Nanomedicine

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ER -

X-ray-induced nanoparticle-based photodynamic therapy of cancer

Abstract

Keywords

UN SDGs

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