TY - JOUR
T1 - Understanding MicroRNA regulation
T2 - A computational perspective
AU - Yue, Dong
AU - Meng, Jia
AU - Lu, Mingzhu
AU - Chen, C. L.Philip
AU - Guo, Maozu
AU - Huang, Yufei
N1 - Funding Information:
Yufei Huang is supported by the National Science Foundation (CCF-0546345), National Institute of Health (R01 CA096512), and Qatar National Research Fund (09-874-3-235). Maozu Guo is supported by the Natural Science Foundation of China (60932008 and 61172098) and Fundamental Research Funds for the Central Universities (HIT.ICRST.2010 022).
PY - 2012/1
Y1 - 2012/1
N2 - Our knowledge of gene regulators presents an intrinsically unbalanced picture inadequate to fully explain the great complexity of their cellular functions. It is now understood that gene regulation assumes multiple modes including transcriptional regulation by transcription factors (TFs) and the posttranscriptional regulation by microRNA (miRNA). MiRNA is a class of small noncoding RNAs of ,22 nucleotides. It is known to repress transcription and/or inhibit translation of a large number of genes by binding mainly to the 3r untranslated region (UTR) of target genes [1], [2]. Elucidating specific functions of miRNAs comprises one of the most active research areas.
AB - Our knowledge of gene regulators presents an intrinsically unbalanced picture inadequate to fully explain the great complexity of their cellular functions. It is now understood that gene regulation assumes multiple modes including transcriptional regulation by transcription factors (TFs) and the posttranscriptional regulation by microRNA (miRNA). MiRNA is a class of small noncoding RNAs of ,22 nucleotides. It is known to repress transcription and/or inhibit translation of a large number of genes by binding mainly to the 3r untranslated region (UTR) of target genes [1], [2]. Elucidating specific functions of miRNAs comprises one of the most active research areas.
UR - http://www.scopus.com/inward/record.url?scp=85032751589&partnerID=8YFLogxK
U2 - 10.1109/MSP.2011.943013
DO - 10.1109/MSP.2011.943013
M3 - Article
AN - SCOPUS:85032751589
SN - 1053-5888
VL - 29
SP - 77
EP - 88
JO - IEEE Signal Processing Magazine
JF - IEEE Signal Processing Magazine
IS - 1
M1 - 6105465
ER -