Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

Judith R. Homberg; Evan J. Kyzar; Michael Nguyen; William H. Norton; Julian Pittman; Manoj K. Poudel; Siddharth Gaikwad; Shun Nakamura; Mamiko Koshiba; Hideo Yamanouchi; Maria Luisa Scattoni; Jeremy F.P. Ullman; David M. Diamond; Aleksandra A. Kaluyeva; Matthew O. Parker; Victor M. Klimenko; Sergey A. Apryatin; Richard E. Brown; Cai Song; Raul R. Gainetdinov; Irving I. Gottesman; Allan V. Kalueff

doi:10.1016/j.neubiorev.2016.03.013

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

Judith R. Homberg, Evan J. Kyzar, Michael Nguyen, William H. Norton, Julian Pittman, Manoj K. Poudel, Siddharth Gaikwad, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi, Maria Luisa Scattoni, Jeremy F.P. Ullman, David M. Diamond, Aleksandra A. Kaluyeva, Matthew O. Parker, Victor M. Klimenko, Sergey A. Apryatin, Richard E. Brown, Cai Song, Raul R. GainetdinovIrving I. Gottesman, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

65 Citations (Scopus)

Abstract

Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

Original language	English
Pages (from-to)	292-312
Number of pages	21
Journal	Neuroscience and Biobehavioral Reviews
Volume	65
DOIs	https://doi.org/10.1016/j.neubiorev.2016.03.013
Publication status	Published - 1 Jun 2016
Externally published	Yes

Keywords

Experimental model
Model organism
Neurodevelopmental disorder
Preclinical study
Translational research

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Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W. H., Pittman, J., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., Scattoni, M. L., Ullman, J. F. P., Diamond, D. M., Kaluyeva, A. A., Parker, M. O., Klimenko, V. M., Apryatin, S. A., Brown, R. E., Song, C., ... Kalueff, A. V. (2016). Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. Neuroscience and Biobehavioral Reviews, 65, 292-312. https://doi.org/10.1016/j.neubiorev.2016.03.013

@article{d82bd1566337489387a3248078ad17ee,

title = "Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models",

abstract = "Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.",

keywords = "Experimental model, Model organism, Neurodevelopmental disorder, Preclinical study, Translational research",

author = "Homberg, {Judith R.} and Kyzar, {Evan J.} and Michael Nguyen and Norton, {William H.} and Julian Pittman and Poudel, {Manoj K.} and Siddharth Gaikwad and Shun Nakamura and Mamiko Koshiba and Hideo Yamanouchi and Scattoni, {Maria Luisa} and Ullman, {Jeremy F.P.} and Diamond, {David M.} and Kaluyeva, {Aleksandra A.} and Parker, {Matthew O.} and Klimenko, {Victor M.} and Apryatin, {Sergey A.} and Brown, {Richard E.} and Cai Song and Gainetdinov, {Raul R.} and Gottesman, {Irving I.} and Kalueff, {Allan V.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.neubiorev.2016.03.013",

language = "English",

volume = "65",

pages = "292--312",

journal = "Neuroscience and Biobehavioral Reviews",

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Homberg, JR, Kyzar, EJ, Nguyen, M, Norton, WH, Pittman, J, Poudel, MK, Gaikwad, S, Nakamura, S, Koshiba, M, Yamanouchi, H, Scattoni, ML, Ullman, JFP, Diamond, DM, Kaluyeva, AA, Parker, MO, Klimenko, VM, Apryatin, SA, Brown, RE, Song, C, Gainetdinov, RR, Gottesman, II & Kalueff, AV 2016, 'Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models', Neuroscience and Biobehavioral Reviews, vol. 65, pp. 292-312. https://doi.org/10.1016/j.neubiorev.2016.03.013

TY - JOUR

T1 - Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

AU - Homberg, Judith R.

AU - Kyzar, Evan J.

AU - Nguyen, Michael

AU - Norton, William H.

AU - Pittman, Julian

AU - Poudel, Manoj K.

AU - Gaikwad, Siddharth

AU - Nakamura, Shun

AU - Koshiba, Mamiko

AU - Yamanouchi, Hideo

AU - Scattoni, Maria Luisa

AU - Ullman, Jeremy F.P.

AU - Diamond, David M.

AU - Kaluyeva, Aleksandra A.

AU - Parker, Matthew O.

AU - Klimenko, Victor M.

AU - Apryatin, Sergey A.

AU - Brown, Richard E.

AU - Song, Cai

AU - Gainetdinov, Raul R.

AU - Gottesman, Irving I.

AU - Kalueff, Allan V.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

AB - Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

KW - Experimental model

KW - Model organism

KW - Neurodevelopmental disorder

KW - Preclinical study

KW - Translational research

UR - http://www.scopus.com/inward/record.url?scp=84963894206&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2016.03.013

DO - 10.1016/j.neubiorev.2016.03.013

M3 - Review article

C2 - 27048961

AN - SCOPUS:84963894206

SN - 0149-7634

VL - 65

SP - 292

EP - 312

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models

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Keywords

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