TY - GEN
T1 - Uncover transcription factor mediated gene regulations using Bayesian nonnegative factor models
AU - Meng, Jia
AU - Chen, Hung I.
AU - Zhang, Jianqiu
AU - Chen, Yidong
AU - Huang, Yufei
PY - 2011
Y1 - 2011
N2 - Transcriptional regulation by transcription factors (TFs) controls when and how much RNA is created. Due to technical limitations, the protein level expressions of TFs are usually unknown, making computational reconstruction of transcriptional network a difficult task. We proposed here a novel Bayesian non-negative factor analysis approach, which is capable to estimate both the non-negative abundances of the transcription factors, their regulatory effects, and sample clustering information by integrating microarray data and existing knowledge regarding TFs regulated target genes; further more, we show that the approach can be slightly altered to include miRNA regulations as well. The results demonstrated its validity and effectiveness to reconstructing transcriptional networks by transcription factors through artificial and real data.
AB - Transcriptional regulation by transcription factors (TFs) controls when and how much RNA is created. Due to technical limitations, the protein level expressions of TFs are usually unknown, making computational reconstruction of transcriptional network a difficult task. We proposed here a novel Bayesian non-negative factor analysis approach, which is capable to estimate both the non-negative abundances of the transcription factors, their regulatory effects, and sample clustering information by integrating microarray data and existing knowledge regarding TFs regulated target genes; further more, we show that the approach can be slightly altered to include miRNA regulations as well. The results demonstrated its validity and effectiveness to reconstructing transcriptional networks by transcription factors through artificial and real data.
UR - http://www.scopus.com/inward/record.url?scp=81055149740&partnerID=8YFLogxK
U2 - 10.1109/ICSPCC.2011.6061806
DO - 10.1109/ICSPCC.2011.6061806
M3 - Conference Proceeding
AN - SCOPUS:81055149740
SN - 9781457708947
T3 - 2011 IEEE International Conference on Signal Processing, Communications and Computing, ICSPCC 2011
BT - 2011 IEEE International Conference on Signal Processing, Communications and Computing, ICSPCC 2011
T2 - 2011 IEEE International Conference on Signal Processing, Communications and Computing, ICSPCC 2011
Y2 - 14 September 2011 through 16 September 2011
ER -