TY - JOUR
T1 - [Tris(pyrazolyl)methane]ruthenium complexes capable of inhibiting cancer cell growth
AU - Walker, Jesse M.
AU - McEwan, Alexis
AU - Pycko, Roxanne
AU - Tassotto, Mary Lynn
AU - Gottardo, Christine
AU - Th'ng, John
AU - Wang, Ruiyao
AU - Spivak, Gregory J.
PY - 2009/11
Y1 - 2009/11
N2 - The [tris(pyrazolyl)methane]ruthenium complexes [(K3-tpm) RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(K3-tpm)RuCl(LL)]PF6 [LL = K 2-dppe, K2-dppp, K2-dppb, (PMePh 2)2] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.
AB - The [tris(pyrazolyl)methane]ruthenium complexes [(K3-tpm) RuCl(solv)2]PF6 [tpm = tris(pyrazolyl)methane; solv = MeCN, dmso] and [(K3-tpm)RuCl(LL)]PF6 [LL = K 2-dppe, K2-dppp, K2-dppb, (PMePh 2)2] have been prepared, characterized and screened in vitro for their antiproliferative properties against the MCF-7 (breast) and HeLa (cervical) cancer cell lines by using the MTT assay. Although the MeCN and dmso complexes showed no activity under the conditions used, the phosphane complexes exhibited remarkable cytotoxic behaviour.
KW - Anticancer agents
KW - Antiproliferative assays
KW - Half-sandwich complexes
KW - Ruthenium
KW - Tris(pyrazolyl)methane
UR - http://www.scopus.com/inward/record.url?scp=72149129164&partnerID=8YFLogxK
U2 - 10.1002/ejic.200900766
DO - 10.1002/ejic.200900766
M3 - Article
AN - SCOPUS:72149129164
SN - 1434-1948
SP - 4629
EP - 4633
JO - European Journal of Inorganic Chemistry
JF - European Journal of Inorganic Chemistry
IS - 31
ER -
