TY - JOUR
T1 - Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies
AU - Kositsyn, Yuriy M.
AU - de Abreu, Murilo S.
AU - Kolesnikova, Tatiana O.
AU - Lagunin, Alexey A.
AU - Poroikov, Vladimir V.
AU - Harutyunyan, Hasmik S.
AU - Yenkoyan, Konstantin B.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/6
Y1 - 2023/6
N2 - Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for the development of novel drug targets for treating depressed and schizophrenic patients. Here, we discuss recent translational advances, research tools and approaches, aiming to facilitate innovative drug discovery in this field. Providing a comprehensive overview of current antidepressants and antipsychotic drugs, we also outline potential novel molecular targets for treating depression and schizophrenia. We also critically evaluate multiple translational challenges and summarize various open questions, in order to foster further integrative cross-discipline research into antidepressant and antipsychotic drug development.
AB - Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for the development of novel drug targets for treating depressed and schizophrenic patients. Here, we discuss recent translational advances, research tools and approaches, aiming to facilitate innovative drug discovery in this field. Providing a comprehensive overview of current antidepressants and antipsychotic drugs, we also outline potential novel molecular targets for treating depression and schizophrenia. We also critically evaluate multiple translational challenges and summarize various open questions, in order to foster further integrative cross-discipline research into antidepressant and antipsychotic drug development.
KW - depression
KW - novel molecular targets
KW - pathogenesis
KW - psychosis
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85161707246&partnerID=8YFLogxK
U2 - 10.3390/ijms24119482
DO - 10.3390/ijms24119482
M3 - Review article
C2 - 37298431
AN - SCOPUS:85161707246
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 11
M1 - 9482
ER -