Total synthesis of the highly N-methylated peptides carmabin a and dragomabin

Baijun Ye; Peng Jiang; Tingrong Zhang; Yuanjun Sun; Xin Hao; Yingjun Cui; Liang Wang; Yue Chen

doi:10.3390/md16090338

Total synthesis of the highly N-methylated peptides carmabin a and dragomabin

Baijun Ye, Peng Jiang, Tingrong Zhang, Yuanjun Sun, Xin Hao, Yingjun Cui, Liang Wang^*, Yue Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

Original language	English
Article number	338
Journal	Marine Drugs
Volume	16
Issue number	9
DOIs	https://doi.org/10.3390/md16090338
Publication status	Published - 17 Sept 2018
Externally published	Yes

Keywords

Carmabin A
Dragomabin
Stereochemical determination/revision
Total synthesis

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10.3390/md16090338

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title = "Total synthesis of the highly N-methylated peptides carmabin a and dragomabin",

abstract = "The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.",

keywords = "Carmabin A, Dragomabin, Stereochemical determination/revision, Total synthesis",

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AU - Ye, Baijun

AU - Jiang, Peng

AU - Zhang, Tingrong

AU - Sun, Yuanjun

AU - Hao, Xin

AU - Cui, Yingjun

AU - Wang, Liang

AU - Chen, Yue

PY - 2018/9/17

Y1 - 2018/9/17

N2 - The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

AB - The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

KW - Carmabin A

KW - Dragomabin

KW - Stereochemical determination/revision

KW - Total synthesis

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DO - 10.3390/md16090338

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ER -

Total synthesis of the highly N-methylated peptides carmabin a and dragomabin

Abstract

Keywords

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