Total Syntheses of Antimalarial Cyclic Tetrapeptides: Koshidacins A and B via Olefin Cross-Metathesis Reactions

Kun Yang; Yue Tong; Tianhao Li; Yuanjun Sun; Liang Wang; Yue Chen

doi:10.1055/a-2541-6275

Total Syntheses of Antimalarial Cyclic Tetrapeptides: Koshidacins A and B via Olefin Cross-Metathesis Reactions

Kun Yang, Yue Tong, Tianhao Li, Yuanjun Sun^*, Liang Wang^*, Yue Chen^*

^*Corresponding author for this work

Nankai University

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we present the first total syntheses of koshidacins A and B, antiplasmodial cyclic tetrapeptides from fungus, by assembling the side chain in late stage through olefin cross-metathesis. Additionally, the two diastereoisomers 8,9- epi -koshidacin A and 9- epi -koshidacin B were also synthesized by our synthetic route.

Original language	English
Article number	SS-2025-01-0019-OP
Pages (from-to)	1875-1884
Number of pages	10
Journal	Synthesis (Germany)
Volume	57
Issue number	11
DOIs	https://doi.org/10.1055/a-2541-6275
Publication status	Accepted/In press - 2025

Keywords

antiplasmodial
cross-metathesis
cyclic tetrapeptides
koshidacin A
koshidacin B
total synthesis

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10.1055/a-2541-6275

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title = "Total Syntheses of Antimalarial Cyclic Tetrapeptides: Koshidacins A and B via Olefin Cross-Metathesis Reactions",

abstract = "In this study, we present the first total syntheses of koshidacins A and B, antiplasmodial cyclic tetrapeptides from fungus, by assembling the side chain in late stage through olefin cross-metathesis. Additionally, the two diastereoisomers 8,9- epi -koshidacin A and 9- epi -koshidacin B were also synthesized by our synthetic route.",

keywords = "antiplasmodial, cross-metathesis, cyclic tetrapeptides, koshidacin A, koshidacin B, total synthesis",

author = "Kun Yang and Yue Tong and Tianhao Li and Yuanjun Sun and Liang Wang and Yue Chen",

year = "2025",

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language = "English",

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T1 - Total Syntheses of Antimalarial Cyclic Tetrapeptides

T2 - Koshidacins A and B via Olefin Cross-Metathesis Reactions

AU - Yang, Kun

AU - Tong, Yue

AU - Li, Tianhao

AU - Sun, Yuanjun

AU - Wang, Liang

AU - Chen, Yue

PY - 2025

Y1 - 2025

N2 - In this study, we present the first total syntheses of koshidacins A and B, antiplasmodial cyclic tetrapeptides from fungus, by assembling the side chain in late stage through olefin cross-metathesis. Additionally, the two diastereoisomers 8,9- epi -koshidacin A and 9- epi -koshidacin B were also synthesized by our synthetic route.

AB - In this study, we present the first total syntheses of koshidacins A and B, antiplasmodial cyclic tetrapeptides from fungus, by assembling the side chain in late stage through olefin cross-metathesis. Additionally, the two diastereoisomers 8,9- epi -koshidacin A and 9- epi -koshidacin B were also synthesized by our synthetic route.

KW - antiplasmodial

KW - cross-metathesis

KW - cyclic tetrapeptides

KW - koshidacin A

KW - koshidacin B

KW - total synthesis

UR - http://www.scopus.com/inward/record.url?scp=105002167707&partnerID=8YFLogxK

U2 - 10.1055/a-2541-6275

DO - 10.1055/a-2541-6275

M3 - Article

AN - SCOPUS:105002167707

SN - 0039-7881

VL - 57

SP - 1875

EP - 1884

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 11

M1 - SS-2025-01-0019-OP

ER -

Total Syntheses of Antimalarial Cyclic Tetrapeptides: Koshidacins A and B via Olefin Cross-Metathesis Reactions

Abstract

Keywords

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