TY - JOUR
T1 - Time to recognize zebrafish 'affective' behavior
AU - Kalueff, Allan V.
AU - Stewart, Adam Michael
AU - Kyzar, Evan J.
AU - Cachat, Jonathan
AU - Gebhardt, Michael
AU - Landsman, Samuel
AU - Robinson, Kyle
AU - Maximino, Caio
AU - Herculano, Anderson Manoel
AU - Jesuthasan, Suresh
AU - Wisenden, Brian
AU - Bally-Cuif, Laure
AU - Lange, Merlin
AU - Vernier, Philippe
AU - Norton, William
AU - Tierney, Keith
AU - Tropepe, Vincent
AU - Neuhauss, Stephan C.F.
PY - 2012
Y1 - 2012
N2 - Widely used in biomedical research, zebrafish (Danio rerio) are steadily gaining popularity as a model organism for studying neurobehavioral phenomena. Here, we focus on to the growing spectrum of zebrafish behavioral phenotypes and the 'bigger' biological problems these models help to address. Emphasizing the developing potential of zebrafish as a model organism in biological psychiatry, we discuss several questions related to this field: Do zebrafish have 'emotional'-like behaviors? What are their neural circuits, biomarkers, and ontogenetic origins? And, finally, how can we use this knowledge to build translational bridges to understand human emotions, motivation and personality? Representing a joint effort of several established neurobehavioral laboratories, this article outlines the mounting evidence to support emotionality in zebrafish and other fishes. This conclusion is important to justify the validity of zebrafish 'affective' paradigms and their utility for basic/translational research of normal and pathological behaviors.
AB - Widely used in biomedical research, zebrafish (Danio rerio) are steadily gaining popularity as a model organism for studying neurobehavioral phenomena. Here, we focus on to the growing spectrum of zebrafish behavioral phenotypes and the 'bigger' biological problems these models help to address. Emphasizing the developing potential of zebrafish as a model organism in biological psychiatry, we discuss several questions related to this field: Do zebrafish have 'emotional'-like behaviors? What are their neural circuits, biomarkers, and ontogenetic origins? And, finally, how can we use this knowledge to build translational bridges to understand human emotions, motivation and personality? Representing a joint effort of several established neurobehavioral laboratories, this article outlines the mounting evidence to support emotionality in zebrafish and other fishes. This conclusion is important to justify the validity of zebrafish 'affective' paradigms and their utility for basic/translational research of normal and pathological behaviors.
KW - behavioral syndromes
KW - biological psychiatry
KW - emotionality
KW - fish models
KW - physiological correlates
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=84870387626&partnerID=8YFLogxK
U2 - 10.1163/1568539X-00003030
DO - 10.1163/1568539X-00003030
M3 - Review article
AN - SCOPUS:84870387626
SN - 0005-7959
VL - 149
SP - 1019
EP - 1036
JO - Behaviour
JF - Behaviour
IS - 10-12
ER -