TY - JOUR
T1 - Therapeutic target database update 2012
T2 - A resource for facilitating target-oriented drug discovery
AU - Zhu, Feng
AU - Shi, Zhe
AU - Qin, Chu
AU - Tao, Lin
AU - Liu, Xin
AU - Xu, Feng
AU - Zhang, Li
AU - Song, Yang
AU - Liu, Xianghui
AU - Zhang, Jingxian
AU - Han, Bucong
AU - Zhang, Peng
AU - Chen, Yuzong
N1 - Funding Information:
Fundamental Research Funds for the Central Universities of China and the Singapore Academic Research Fund R-148-000-141-750 and R-148-000-141-646. Funding for open access charge: Fundamental Research Funds for the Central Universities of China.
PY - 2012/1
Y1 - 2012/1
N2 - Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ ttd.asp) has been developed to provide comprehensive information about efficacy targets and the corresponding approved, clinical trial and investigative drugs. Since its last update, major improvements and updates have been made to TTD. In addition to the significant increase of data content (from 1894 targets and 5028 drugs to 2025 targets and 17 816 drugs), we added target validation information (drug potency against target, effect against disease models and effect of target knockout, knockdown or genetic variations) for 932 targets, and 841 quantitative structure activity relationship models for active compounds of 228 chemical types against 121 targets. Moreover, we added the data from our previous drug studies including 3681 multi-target agents against 108 target pairs, 116 drug combinations with their synergistic, additive, antagonistic, potentiative or reductive mechanisms, 1427 natural product-derived approved, clinical trial and pre-clinical drugs and cross-links to the clinical trial information page in the ClinicalTrials.gov database for 770 clinical trial drugs. These updates are useful for facilitating target discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations.
AB - Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ ttd.asp) has been developed to provide comprehensive information about efficacy targets and the corresponding approved, clinical trial and investigative drugs. Since its last update, major improvements and updates have been made to TTD. In addition to the significant increase of data content (from 1894 targets and 5028 drugs to 2025 targets and 17 816 drugs), we added target validation information (drug potency against target, effect against disease models and effect of target knockout, knockdown or genetic variations) for 932 targets, and 841 quantitative structure activity relationship models for active compounds of 228 chemical types against 121 targets. Moreover, we added the data from our previous drug studies including 3681 multi-target agents against 108 target pairs, 116 drug combinations with their synergistic, additive, antagonistic, potentiative or reductive mechanisms, 1427 natural product-derived approved, clinical trial and pre-clinical drugs and cross-links to the clinical trial information page in the ClinicalTrials.gov database for 770 clinical trial drugs. These updates are useful for facilitating target discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations.
UR - http://www.scopus.com/inward/record.url?scp=84859267371&partnerID=8YFLogxK
U2 - 10.1093/nar/gkr797
DO - 10.1093/nar/gkr797
M3 - Article
C2 - 21948793
AN - SCOPUS:84859267371
SN - 0305-1048
VL - 40
SP - D1128-D1136
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -