TY - JOUR
T1 - The developing utility of zebrafish models of neurological and neuropsychiatric disorders
T2 - A critical review
AU - Fontana, Barbara D.
AU - Mezzomo, Nathana J.
AU - Kalueff, Allan V.
AU - Rosemberg, Denis B.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.
AB - Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.
KW - Brain function
KW - Neurological diseases
KW - Neuropsychopharmacology
KW - Psychiatric disorder
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85032361535&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2017.10.004
DO - 10.1016/j.expneurol.2017.10.004
M3 - Review article
C2 - 28987462
AN - SCOPUS:85032361535
SN - 0014-4886
VL - 299
SP - 157
EP - 171
JO - Experimental Neurology
JF - Experimental Neurology
ER -