TY - JOUR
T1 - Temporal stability of novelty exploration in mice exposed to different open field tests
AU - Kalueff, Allan V.
AU - Keisala, Tiina
AU - Minasyan, Anna
AU - Kuuslahti, Marianne
AU - Tuohimaa, Pentti
PY - 2006/3
Y1 - 2006/3
N2 - We investigated behavioural activity and temporal distribution (patterning) of mouse exploration in different open field (OF) arenas. Mice of 129S1 (S1) strain were subjected in parallel to three different OF arenas (Experiment 1), two different OF arenas in two trials (Experiment 2) or two trials of the same OF test (Experiment 3). Overall, mice demonstrated a high degree of similarity in the temporal profile of novelty-induced horizontal and vertical exploration (regardless of the size, colour and shape of the OF), which remained stable in subsequent OF exposures. In Experiments 4 and 5, we tested F1 hybrid mice (BALB/c-S1; NMRI-S1), and Vitamin D receptor knockout mice (generated on S1 genetic background), again showing strikingly similar temporal patterns of their OF exploration, despite marked behavioural strain differences in anxiety and activity. These results suggest that mice are characterised by stability of temporal organization of their exploration in different OF novelty situations.
AB - We investigated behavioural activity and temporal distribution (patterning) of mouse exploration in different open field (OF) arenas. Mice of 129S1 (S1) strain were subjected in parallel to three different OF arenas (Experiment 1), two different OF arenas in two trials (Experiment 2) or two trials of the same OF test (Experiment 3). Overall, mice demonstrated a high degree of similarity in the temporal profile of novelty-induced horizontal and vertical exploration (regardless of the size, colour and shape of the OF), which remained stable in subsequent OF exposures. In Experiments 4 and 5, we tested F1 hybrid mice (BALB/c-S1; NMRI-S1), and Vitamin D receptor knockout mice (generated on S1 genetic background), again showing strikingly similar temporal patterns of their OF exploration, despite marked behavioural strain differences in anxiety and activity. These results suggest that mice are characterised by stability of temporal organization of their exploration in different OF novelty situations.
KW - Exploration stability
KW - Mice
KW - Novelty
KW - Open field
KW - Temporal patterning
UR - http://www.scopus.com/inward/record.url?scp=32344449905&partnerID=8YFLogxK
U2 - 10.1016/j.beproc.2005.12.011
DO - 10.1016/j.beproc.2005.12.011
M3 - Article
C2 - 16442749
AN - SCOPUS:32344449905
SN - 0376-6357
VL - 72
SP - 104
EP - 112
JO - Behavioural Processes
JF - Behavioural Processes
IS - 1
ER -