TY - JOUR
T1 - Synthesis of isoquinolinones via regioselective palladium-catalyzed C–H activation/annulation
AU - Qi, Wenke
AU - Wu, Yimei
AU - Han, Yongxu
AU - Li, Yi
N1 - Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2017/11
Y1 - 2017/11
N2 - The isoquinoline motif and its derivatives are of significant interest due to their important biological activities. The effective synthesis of substituted isoquinoline compounds has historically been a significant challenge. A new palladium-catalyzed C–H activation/annulation of N-methoxy benzamides and 2,3-allenoic acid esters is described. For the first time, 2,3-allenoic acid esters are employed for the syntheses of 3,4-substituted hydroisoquinolones, the heteroannulation of allenes proceeded smoothly and afforded the products with good yields and excellent regioselectivity.
AB - The isoquinoline motif and its derivatives are of significant interest due to their important biological activities. The effective synthesis of substituted isoquinoline compounds has historically been a significant challenge. A new palladium-catalyzed C–H activation/annulation of N-methoxy benzamides and 2,3-allenoic acid esters is described. For the first time, 2,3-allenoic acid esters are employed for the syntheses of 3,4-substituted hydroisoquinolones, the heteroannulation of allenes proceeded smoothly and afforded the products with good yields and excellent regioselectivity.
KW - 2,3-allenoic acid esters
KW - C–H activation
KW - C–H functionalization
KW - Hydroisoquinolinones
KW - Palladium-catalyzed annulation
KW - Transition-metal catalyst
UR - http://www.scopus.com/inward/record.url?scp=85033553391&partnerID=8YFLogxK
U2 - 10.3390/catal7110320
DO - 10.3390/catal7110320
M3 - Article
AN - SCOPUS:85033553391
SN - 2073-4344
VL - 7
JO - Catalysts
JF - Catalysts
IS - 11
M1 - 320
ER -