Synthesis and biological evaluation of novel selenonucleosides

Yao Chen, Yingdan Peng, Jiancun Zhang, Lei Fu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents.

Original languageEnglish
Pages (from-to)1001-1008
Number of pages8
JournalNucleosides, Nucleotides and Nucleic Acids
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 2008
Externally publishedYes

Keywords

  • 1,4-oxaselenane
  • Biological evaluation
  • Selenonucleoside
  • Synthesis

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