TY - JOUR
T1 - Synthesis and antimicrobial evaluation of new benzofuran derivatives
AU - Jiang, Xizhen
AU - Liu, Wenlu
AU - Zhang, Wei
AU - Jiang, Faqin
AU - Gao, Zhe
AU - Zhuang, Hao
AU - Fu, Lei
N1 - Funding Information:
We thanked the National Comprehensive Technology Platforms for Innovative Drug R&D, 2009ZX09301-007 for the financial support. We also thanked Zhao’s Laboratory for the supplies about the MIC 80 test.
PY - 2011/8
Y1 - 2011/8
N2 - Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 μg/mL), which were better than the control drugs.
AB - Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC80 = 0.39-3.12 μg/mL), which were better than the control drugs.
KW - Anti-microorganism
KW - Benzofuran
KW - Stilbenoid
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=79958275800&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2011.04.053
DO - 10.1016/j.ejmech.2011.04.053
M3 - Article
C2 - 21570749
AN - SCOPUS:79958275800
SN - 0223-5234
VL - 46
SP - 3526
EP - 3530
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 8
ER -