Surface-enhanced Raman spectroscopy investigation on human breast cancer cells

Jichun Zhu; Jing Zhou; Jianyu Guo; Weiying Cai; Bo Liu; Zugeng Wang; Zhenrong Sun

doi:10.1186/1752-153X-7-37

Surface-enhanced Raman spectroscopy investigation on human breast cancer cells

Jichun Zhu, Jing Zhou, Jianyu Guo, Weiying Cai, Bo Liu, Zugeng Wang, Zhenrong Sun^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Background: Nanoparticles are potentially used for early cancer detection, accurate diagnosis, and cancer treatment.Results: In this paper, the breast cancer cells treated with gold colloidal suspension were carefully studied by surface-enhanced Raman scattering (SERS) spectra. Raman spectroscopy combining with high-resolution electron microscope is employed to investigate the interaction of gold nanoparticles (GNPs) with the intracellular components. The TEM images show that the GNPs are taken into the living cells and enveloped into some vesicles named 'lick up vesicles' in the cytosol.Conclusions: The SERS spectra and SERS mapping of cells indicate that the major Raman bands are mostly assigned to the vibration characteristics of proteins, and the C-H in-plane bending mode of the substituted benzene in Phenylalanine is remarkably enhanced. Finally, the interaction mechanisms of the GNPs with the intracellular components are further discussed in detail.

Original language	English
Article number	37
Journal	Chemistry Central Journal
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/1752-153X-7-37
Publication status	Published - 25 Feb 2013
Externally published	Yes

Keywords

Breast cancer cell
Gold nanoparticles
SERS
SERS mapping

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1752-153X-7-37

Cite this

@article{c47f013f2fbd4b488b5b2395960c4cb4,

title = "Surface-enhanced Raman spectroscopy investigation on human breast cancer cells",

abstract = "Background: Nanoparticles are potentially used for early cancer detection, accurate diagnosis, and cancer treatment.Results: In this paper, the breast cancer cells treated with gold colloidal suspension were carefully studied by surface-enhanced Raman scattering (SERS) spectra. Raman spectroscopy combining with high-resolution electron microscope is employed to investigate the interaction of gold nanoparticles (GNPs) with the intracellular components. The TEM images show that the GNPs are taken into the living cells and enveloped into some vesicles named 'lick up vesicles' in the cytosol.Conclusions: The SERS spectra and SERS mapping of cells indicate that the major Raman bands are mostly assigned to the vibration characteristics of proteins, and the C-H in-plane bending mode of the substituted benzene in Phenylalanine is remarkably enhanced. Finally, the interaction mechanisms of the GNPs with the intracellular components are further discussed in detail.",

keywords = "Breast cancer cell, Gold nanoparticles, SERS, SERS mapping",

author = "Jichun Zhu and Jing Zhou and Jianyu Guo and Weiying Cai and Bo Liu and Zugeng Wang and Zhenrong Sun",

year = "2013",

month = feb,

day = "25",

doi = "10.1186/1752-153X-7-37",

language = "English",

volume = "7",

journal = "Chemistry Central Journal",

issn = "1752-153X",

number = "1",

}

TY - JOUR

T1 - Surface-enhanced Raman spectroscopy investigation on human breast cancer cells

AU - Zhu, Jichun

AU - Zhou, Jing

AU - Guo, Jianyu

AU - Cai, Weiying

AU - Liu, Bo

AU - Wang, Zugeng

AU - Sun, Zhenrong

PY - 2013/2/25

Y1 - 2013/2/25

N2 - Background: Nanoparticles are potentially used for early cancer detection, accurate diagnosis, and cancer treatment.Results: In this paper, the breast cancer cells treated with gold colloidal suspension were carefully studied by surface-enhanced Raman scattering (SERS) spectra. Raman spectroscopy combining with high-resolution electron microscope is employed to investigate the interaction of gold nanoparticles (GNPs) with the intracellular components. The TEM images show that the GNPs are taken into the living cells and enveloped into some vesicles named 'lick up vesicles' in the cytosol.Conclusions: The SERS spectra and SERS mapping of cells indicate that the major Raman bands are mostly assigned to the vibration characteristics of proteins, and the C-H in-plane bending mode of the substituted benzene in Phenylalanine is remarkably enhanced. Finally, the interaction mechanisms of the GNPs with the intracellular components are further discussed in detail.

AB - Background: Nanoparticles are potentially used for early cancer detection, accurate diagnosis, and cancer treatment.Results: In this paper, the breast cancer cells treated with gold colloidal suspension were carefully studied by surface-enhanced Raman scattering (SERS) spectra. Raman spectroscopy combining with high-resolution electron microscope is employed to investigate the interaction of gold nanoparticles (GNPs) with the intracellular components. The TEM images show that the GNPs are taken into the living cells and enveloped into some vesicles named 'lick up vesicles' in the cytosol.Conclusions: The SERS spectra and SERS mapping of cells indicate that the major Raman bands are mostly assigned to the vibration characteristics of proteins, and the C-H in-plane bending mode of the substituted benzene in Phenylalanine is remarkably enhanced. Finally, the interaction mechanisms of the GNPs with the intracellular components are further discussed in detail.

KW - Breast cancer cell

KW - Gold nanoparticles

KW - SERS

KW - SERS mapping

UR - http://www.scopus.com/inward/record.url?scp=84874122121&partnerID=8YFLogxK

U2 - 10.1186/1752-153X-7-37

DO - 10.1186/1752-153X-7-37

M3 - Article

AN - SCOPUS:84874122121

SN - 1752-153X

VL - 7

JO - Chemistry Central Journal

JF - Chemistry Central Journal

IS - 1

M1 - 37

ER -

Surface-enhanced Raman spectroscopy investigation on human breast cancer cells

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this