TY - JOUR
T1 - Solfeggio-frequency music exposure reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish
AU - dos Santos, Amanda C.
AU - de Abreu, Murilo S.
AU - de Mello, Gabriel P.
AU - Costella, Vanusa
AU - do Amaral, Nicoli R.
AU - Zanella, Alexander
AU - Poletto, Júlia
AU - Petersen, Elena V.
AU - Kalueff, Allan V.
AU - Giacomini, Ana C.V.V.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/7/26
Y1 - 2023/7/26
N2 - Music therapy has long been used as a non-pharmacological intervention to improve cognitive function and mood in humans. Mounting rodent evidence also supports beneficial impact of music exposure on animal cognitive performance. The zebrafish (Danio rerio) is an important emerging aquatic animal model in translational biomedical and neuroscience research. Here, we evaluate the effects of intermittent (2-h or 6-h twice daily) and continuous (24-h) solfeggio-frequency music exposure on behavioral, cognitive and endocrine parameters in adult zebrafish whose circadian rhythm was disturbed by a 24-h light exposure. Overall, a 24-h light exposure stress evokes overt cognitive deficits in the inhibitory avoidance test and elevates zebrafish whole-body cortisol levels. However, these effects were reversed by solfeggio-frequency music exposure for 2 or 6 h twice daily, and by continuous 24-h exposure. Collectively, these findings suggest a positive modulation of cognitive and endocrine responses in adult zebrafish by environmental enrichment via the long-term exposure to music, and reinforces zebrafish as a robust, sensitive model organism for neurocognitive and neuroendocrine research.
AB - Music therapy has long been used as a non-pharmacological intervention to improve cognitive function and mood in humans. Mounting rodent evidence also supports beneficial impact of music exposure on animal cognitive performance. The zebrafish (Danio rerio) is an important emerging aquatic animal model in translational biomedical and neuroscience research. Here, we evaluate the effects of intermittent (2-h or 6-h twice daily) and continuous (24-h) solfeggio-frequency music exposure on behavioral, cognitive and endocrine parameters in adult zebrafish whose circadian rhythm was disturbed by a 24-h light exposure. Overall, a 24-h light exposure stress evokes overt cognitive deficits in the inhibitory avoidance test and elevates zebrafish whole-body cortisol levels. However, these effects were reversed by solfeggio-frequency music exposure for 2 or 6 h twice daily, and by continuous 24-h exposure. Collectively, these findings suggest a positive modulation of cognitive and endocrine responses in adult zebrafish by environmental enrichment via the long-term exposure to music, and reinforces zebrafish as a robust, sensitive model organism for neurocognitive and neuroendocrine research.
KW - Circadian rhythm
KW - Cognition
KW - Cortisol
KW - Music exposure
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85159170429&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2023.114461
DO - 10.1016/j.bbr.2023.114461
M3 - Article
C2 - 37119977
AN - SCOPUS:85159170429
SN - 0166-4328
VL - 450
JO - Behavioural Brain Research
JF - Behavioural Brain Research
M1 - 114461
ER -