Role of key endocannabinoids and their receptors in breast cancer

Mikhail G. Akimov; Polina V. Dudina; Tatiana V. Vyunova; Allan V. Kalueff; Natalia M. Gretskaya; Vladimir V. Bezuglov

doi:10.17816/RCF623144

Role of key endocannabinoids and their receptors in breast cancer

Mikhail G. Akimov, Polina V. Dudina, Tatiana V. Vyunova^*, Allan V. Kalueff, Natalia M. Gretskaya, Vladimir V. Bezuglov

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system’s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer.

Original language	English
Pages (from-to)	41-51
Number of pages	11
Journal	Reviews on Clinical Pharmacology and Drug Therapy
Volume	22
Issue number	1
DOIs	https://doi.org/10.17816/RCF623144
Publication status	Published - 2024
Externally published	Yes

Keywords

anandamide
breast cancer
endocannabinoids
lysophosphatidylinositol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.17816/RCF623144

Cite this

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title = "Role of key endocannabinoids and their receptors in breast cancer",

abstract = "Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system{\textquoteright}s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer.",

keywords = "anandamide, breast cancer, endocannabinoids, lysophosphatidylinositol",

author = "Akimov, {Mikhail G.} and Dudina, {Polina V.} and Vyunova, {Tatiana V.} and Kalueff, {Allan V.} and Gretskaya, {Natalia M.} and Bezuglov, {Vladimir V.}",

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year = "2024",

doi = "10.17816/RCF623144",

language = "English",

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pages = "41--51",

journal = "Reviews on Clinical Pharmacology and Drug Therapy",

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TY - JOUR

T1 - Role of key endocannabinoids and their receptors in breast cancer

AU - Akimov, Mikhail G.

AU - Dudina, Polina V.

AU - Vyunova, Tatiana V.

AU - Kalueff, Allan V.

AU - Gretskaya, Natalia M.

AU - Bezuglov, Vladimir V.

N1 - Publisher Copyright: © Eco-Vector, 2024.

PY - 2024

Y1 - 2024

N2 - Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system’s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer.

AB - Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system’s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer.

KW - anandamide

KW - breast cancer

KW - endocannabinoids

KW - lysophosphatidylinositol

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U2 - 10.17816/RCF623144

DO - 10.17816/RCF623144

M3 - Review article

AN - SCOPUS:85192835073

SN - 1683-4100

VL - 22

SP - 41

EP - 51

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

IS - 1

ER -

Role of key endocannabinoids and their receptors in breast cancer

Abstract

Keywords

UN SDGs

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