TY - JOUR
T1 - Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders
AU - Alexiou, Athanasios
AU - Soursou, Georgia
AU - Chatzichronis, Stylianos
AU - Gasparatos, Ermis
AU - Kamal, Mohammad Amjad
AU - Yarla, Nagendra Sastry
AU - Perveen, Asma
AU - Barreto, George E.
AU - Ashraf, Ghulam Md
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer’s disease, and other central nervous system (CNS)-related disorders like the Parkinson’s disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.
AB - Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer’s disease, and other central nervous system (CNS)-related disorders like the Parkinson’s disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.
KW - Alzheimer’s disease
KW - Mitochondria
KW - Mitochondrial dynamics
KW - Neurodegenerative diseases
KW - Oxidative stress
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85055553727&partnerID=8YFLogxK
U2 - 10.1007/s12035-018-1397-x
DO - 10.1007/s12035-018-1397-x
M3 - Review article
C2 - 30338485
AN - SCOPUS:85055553727
SN - 0893-7648
VL - 56
SP - 4530
EP - 4538
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 6
ER -