Role of GABA in anxiety and depression

Allan V. Kalueff; David J. Nutt

doi:10.1002/da.20262

Role of GABA in anxiety and depression

Allan V. Kalueff, David J. Nutt^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

410 Citations (Scopus)

Abstract

This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overtop in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.

Original language	English
Pages (from-to)	495-517
Number of pages	23
Journal	Depression and Anxiety
Volume	24
Issue number	7
DOIs	https://doi.org/10.1002/da.20262
Publication status	Published - 2007
Externally published	Yes

Keywords

Anxiety
Benzodiazepine receptors
Common pathogenesis
Depression
GABA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/da.20262

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title = "Role of GABA in anxiety and depression",

abstract = "This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overtop in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.",

keywords = "Anxiety, Benzodiazepine receptors, Common pathogenesis, Depression, GABA",

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AU - Nutt, David J.

PY - 2007

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AB - This review assesses the parallel data on the role of gamma-aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overtop in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed.

KW - Anxiety

KW - Benzodiazepine receptors

KW - Common pathogenesis

KW - Depression

KW - GABA

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JO - Depression and Anxiety

JF - Depression and Anxiety

IS - 7

ER -

Role of GABA in anxiety and depression

Abstract

Keywords

UN SDGs

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