TY - JOUR
T1 - Reno-protective effect of garlic extract against immobilization stress induced changes in rats
AU - Zaidi, Syed Kashif
AU - Ansari, Shakeel Ahmed
AU - Ashraf, Ghulam Md
AU - Jafri, Mohammad Alam
AU - Tabrez, Shams
AU - Banu, Naheed
N1 - Publisher Copyright:
© 2015 Hainan Medical University. Production and hosting by Elsevier B.V. All rights reserved.
PY - 2015
Y1 - 2015
N2 - OBJECTIVE: To examine immobilization stress-induced antioxidant defense alterations in rat kidney and the antioxidant effects of aqueous garlic extract in pre and post stress extract treatments. METHODS: Albino rats were treated with aqueous extract of garlic both before and 6 h of immobilization stress. Pro-oxidant eminence of rat kidney was assessed by determining the levels of glutathione, thiobarbituric acid reactive substances, aspartate aminotransferase, alanine aminotransferase, glucose, uric acid, alkaline phosphatase and antioxidant enzymes activities. RESULTS: In response to 6 h of immobilization stress, a significant rise in the level of kidney enzymes was recorded. However, antioxidant enzyme activities showed a sharp decline. CONCLUSIONS: The extract treatment before and after the stress reverted the activities of above mentioned enzymes towards their control values. Hence, garlic extract can be given as nutritional supplement for scavenging the free radicals generated in rat kidney.
AB - OBJECTIVE: To examine immobilization stress-induced antioxidant defense alterations in rat kidney and the antioxidant effects of aqueous garlic extract in pre and post stress extract treatments. METHODS: Albino rats were treated with aqueous extract of garlic both before and 6 h of immobilization stress. Pro-oxidant eminence of rat kidney was assessed by determining the levels of glutathione, thiobarbituric acid reactive substances, aspartate aminotransferase, alanine aminotransferase, glucose, uric acid, alkaline phosphatase and antioxidant enzymes activities. RESULTS: In response to 6 h of immobilization stress, a significant rise in the level of kidney enzymes was recorded. However, antioxidant enzyme activities showed a sharp decline. CONCLUSIONS: The extract treatment before and after the stress reverted the activities of above mentioned enzymes towards their control values. Hence, garlic extract can be given as nutritional supplement for scavenging the free radicals generated in rat kidney.
KW - ALT
KW - Antioxidant enzymes
KW - AST
KW - Garlic
KW - MDA
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=84954541178&partnerID=8YFLogxK
U2 - 10.1016/S2221-1691(15)30370-1
DO - 10.1016/S2221-1691(15)30370-1
M3 - Article
AN - SCOPUS:84954541178
SN - 2221-1691
VL - 5
SP - 364
EP - 369
JO - Asian Pacific Journal of Tropical Biomedicine
JF - Asian Pacific Journal of Tropical Biomedicine
IS - 5
ER -