TY - JOUR
T1 - Refining psychiatric genetics
T2 - From 'mouse psychiatry' to understanding complex human disorders
AU - Laporte, Justin L.
AU - Ren-Patterson, Renee F.
AU - Murphy, Dennis L.
AU - Kalueff, Allan V.
PY - 2008/9
Y1 - 2008/9
N2 - Investigating the pathogenesis of psychiatric disorders is a complicated and rigorous task for psychiatric geneticistsas the disorders often involve combinations of genetic, behavioral, personality, and environmental factors. To nurture further progress in this field, a new set of conceptual tools is needed in addition to the currently accepted approaches. Concepts that consider cross-species trait genetics and the interplay between the domains of disorders, as well as the full spectrum of potential symptoms and their place along the pathogenetic continuum, are particularly important to address these needs. Here, we outline recent concepts and approaches that can help refine the field and enable more precise dissection of the genetic mechanisms contributing to psychiatric disorders.
AB - Investigating the pathogenesis of psychiatric disorders is a complicated and rigorous task for psychiatric geneticistsas the disorders often involve combinations of genetic, behavioral, personality, and environmental factors. To nurture further progress in this field, a new set of conceptual tools is needed in addition to the currently accepted approaches. Concepts that consider cross-species trait genetics and the interplay between the domains of disorders, as well as the full spectrum of potential symptoms and their place along the pathogenetic continuum, are particularly important to address these needs. Here, we outline recent concepts and approaches that can help refine the field and enable more precise dissection of the genetic mechanisms contributing to psychiatric disorders.
KW - Behavioral domains
KW - Genetic factors
KW - Psychiatric disorders
KW - Spectrum nature of pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=58149337611&partnerID=8YFLogxK
U2 - 10.1097/FBP.0b013e32830dc09b
DO - 10.1097/FBP.0b013e32830dc09b
M3 - Review article
C2 - 18690099
AN - SCOPUS:58149337611
SN - 0955-8810
VL - 19
SP - 377
EP - 384
JO - Behavioural Pharmacology
JF - Behavioural Pharmacology
IS - 5-6
ER -
