Recent updates on the association between Alzheimer's disease and vascular dementia

Ghulam M. Ashraf; Sandesh Chibber; Syed K. Zaidi; Shams Tabrez; Ausaf Ahmad; Shazi Shakil; Gohar Mushtaq; Saleh S. Baeesa; Mohammad A. Kamal

doi:10.2174/1573406411666151030111820

Recent updates on the association between Alzheimer's disease and vascular dementia

Ghulam M. Ashraf, Sandesh Chibber, Syed K. Zaidi, Shams Tabrez, Ausaf Ahmad, Shazi Shakil, Gohar Mushtaq, Saleh S. Baeesa, Mohammad A. Kamal^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

44 Citations (Scopus)

Abstract

The two most common forms of dementia are Alzheimer's disease (AD) followed by vascular dementia (VaD), together accounting for a whopping 60-80% of total dementia cases worldwide. Even though these diseases are recognized as 'common', they still remain underdiagnosed. Recent research suggests that AD and VaD are closely intertwined. The symptoms of AD and VaD can be similar and the two conditions can occur simultaneously. A large number of patients diagnosed with AD have also been reported with VaD-caused brain damage. Moreover, both the diseases have been reported to have similar risk factors. The overlap between these diseases is important because the lifestyle changes and medications prescribed to curb one of these diseases may also help curb the other. In the present review, we present an inclusive outline of the parallelism between AD and VaD by exploring potential commonalities at the mechanistic and therapeutic levels.

Original language	English
Pages (from-to)	226-237
Number of pages	12
Journal	Medicinal Chemistry
Volume	12
Issue number	3
DOIs	https://doi.org/10.2174/1573406411666151030111820
Publication status	Published - 1 May 2016
Externally published	Yes

Keywords

Alzheimer's disease
Dementia
Insulin resistance syndrome
Nitric oxide
Reactive oxygen species
Therapy
Vascular dementia

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10.2174/1573406411666151030111820

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title = "Recent updates on the association between Alzheimer's disease and vascular dementia",

abstract = "The two most common forms of dementia are Alzheimer's disease (AD) followed by vascular dementia (VaD), together accounting for a whopping 60-80% of total dementia cases worldwide. Even though these diseases are recognized as 'common', they still remain underdiagnosed. Recent research suggests that AD and VaD are closely intertwined. The symptoms of AD and VaD can be similar and the two conditions can occur simultaneously. A large number of patients diagnosed with AD have also been reported with VaD-caused brain damage. Moreover, both the diseases have been reported to have similar risk factors. The overlap between these diseases is important because the lifestyle changes and medications prescribed to curb one of these diseases may also help curb the other. In the present review, we present an inclusive outline of the parallelism between AD and VaD by exploring potential commonalities at the mechanistic and therapeutic levels.",

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AU - Chibber, Sandesh

AU - Zaidi, Syed K.

AU - Tabrez, Shams

AU - Ahmad, Ausaf

AU - Shakil, Shazi

AU - Mushtaq, Gohar

AU - Baeesa, Saleh S.

AU - Kamal, Mohammad A.

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KW - Insulin resistance syndrome

KW - Nitric oxide

KW - Reactive oxygen species

KW - Therapy

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Recent updates on the association between Alzheimer's disease and vascular dementia

Abstract

Keywords

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