TY - JOUR
T1 - Rapidly monitorable drug loading system for self-illuminating anticancer via self-enhanced aggregation-induced electrochemiluminescence polymer dots
AU - Wang, Ziyu
AU - Liu, Peng
AU - Pei, Yang
AU - Li, Yulin
AU - Wang, Cheng
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2
Y1 - 2023/2
N2 - As a representative of “smart” drug delivery systems (DDSs), multi-functional DDSs is of great significance in the field of drug research and development. Meanwhile, the rapid monitoring of the drug loading ratios is a significant work to study the therapeutic activity of DDSs. Therefore, we develop an efficient drug loading monitorable DDS based on self-enhanced aggregation-induced electrochemiluminescence (AIECL) bi-functional polymer dots (Pdots) for self-illuminating therapy. In detail, a self-enhanced AIECL conjugated polymer is synthesized and modified with tertiary amine as ECL co-reactive group. After anticancer drug doxorubicin (DOX) is loaded in, the ECL signal of Pdots can be gradually quenched by increasing DOX ratios to give a low limit of detection as 0.9% (mDOX/mpolymer), indicating its good performance in the rapid monitoring of drug loading. The drug loaded Pdots can not only indicate their location in cancer cells but also exhibit obvious anticancer property, which demonstrates its application in self-illuminating anticancer therapy. This work reports a novel strategy for accurate and rapid monitoring of the drug loading ratios in DDSs preparation and exhibits its positive role in advanced DDSs developments, which is of great significance in promoting its research development and improving personal and public health.
AB - As a representative of “smart” drug delivery systems (DDSs), multi-functional DDSs is of great significance in the field of drug research and development. Meanwhile, the rapid monitoring of the drug loading ratios is a significant work to study the therapeutic activity of DDSs. Therefore, we develop an efficient drug loading monitorable DDS based on self-enhanced aggregation-induced electrochemiluminescence (AIECL) bi-functional polymer dots (Pdots) for self-illuminating therapy. In detail, a self-enhanced AIECL conjugated polymer is synthesized and modified with tertiary amine as ECL co-reactive group. After anticancer drug doxorubicin (DOX) is loaded in, the ECL signal of Pdots can be gradually quenched by increasing DOX ratios to give a low limit of detection as 0.9% (mDOX/mpolymer), indicating its good performance in the rapid monitoring of drug loading. The drug loaded Pdots can not only indicate their location in cancer cells but also exhibit obvious anticancer property, which demonstrates its application in self-illuminating anticancer therapy. This work reports a novel strategy for accurate and rapid monitoring of the drug loading ratios in DDSs preparation and exhibits its positive role in advanced DDSs developments, which is of great significance in promoting its research development and improving personal and public health.
KW - Multi-functional drug delivery system
KW - Rapidly drug loading monitoring
KW - Self-enhanced aggregation-induced electrochemiluminescence
KW - Self-illuminating anticancer
UR - http://www.scopus.com/inward/record.url?scp=85145848167&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2022.104137
DO - 10.1016/j.jddst.2022.104137
M3 - Article
AN - SCOPUS:85145848167
SN - 1773-2247
VL - 80
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 104137
ER -