Qui non proficit, deficit: Experimental models for 'integrative' research of affective disorders

Justin L. LaPorte, Rupert J. Egan, Peter C. Hart, Carisa L. Bergner, Jonathan M. Cachat, Peter R. Canavello, Allan V. Kalueff*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Experimental models are an important tool for the study of biological mechanisms of psychiatric disorders. Although encouraging progress has been made in biological psychiatry of affective disorders, there remain numerous methodological, conceptual, and translational challenges in this field. Mounting clinical data support the view that psychiatric disorders as spectra, rather than as discrete or isolated illnesses. This requires new theories as well as new animal paradigms for "integrative" modeling of psychiatric disorders and their spectra. Here we discuss recent "integrative" experimental models and concepts that promise to advance translational research of affective disorders.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Affective Disorders
Volume121
Issue number1-2
DOIs
Publication statusPublished - Feb 2010
Externally publishedYes

Keywords

  • Affective disorders
  • Experimental models
  • Gene × environment × behavior interactions
  • Translational research

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