Proteins commonly linked to autism spectrum disorder and Alzheimer's disease

Athanasios Alexiou; Georgia Soursou; Nagendra Sastry Yarla; Ghulam Md Ashraf

doi:10.2174/1389203718666170911145321

Proteins commonly linked to autism spectrum disorder and Alzheimer's disease

Athanasios Alexiou^*, Georgia Soursou, Nagendra Sastry Yarla, Ghulam Md Ashraf

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Several years after the first publication of Barker's Hypothesis the identification of common patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the increasing number of diagnosed cases globally, scientists focused on commonly expressed and related proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer’s Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules that play a fundamental role in their development. These proteins are described and analyzed concerning the underlying pathology of these diseases.

Original language	English
Pages (from-to)	876-880
Number of pages	5
Journal	Current Protein and Peptide Science
Volume	19
Issue number	9
DOIs	https://doi.org/10.2174/1389203718666170911145321
Publication status	Published - 2018
Externally published	Yes

Keywords

Alzheimer’s disease
Autism spectrum disorder
Developmental origins of health and diseases
Neurological symptoms
Proteins

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10.2174/1389203718666170911145321

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title = "Proteins commonly linked to autism spectrum disorder and Alzheimer's disease",

abstract = "Several years after the first publication of Barker's Hypothesis the identification of common patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the increasing number of diagnosed cases globally, scientists focused on commonly expressed and related proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer{\textquoteright}s Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules that play a fundamental role in their development. These proteins are described and analyzed concerning the underlying pathology of these diseases.",

keywords = "Alzheimer{\textquoteright}s disease, Autism spectrum disorder, Developmental origins of health and diseases, Neurological symptoms, Proteins",

author = "Athanasios Alexiou and Georgia Soursou and Yarla, {Nagendra Sastry} and {Md Ashraf}, Ghulam",

note = "Publisher Copyright: {\textcopyright} 2018 Bentham Science Publishers.",

year = "2018",

doi = "10.2174/1389203718666170911145321",

language = "English",

volume = "19",

pages = "876--880",

journal = "Current Protein and Peptide Science",

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T1 - Proteins commonly linked to autism spectrum disorder and Alzheimer's disease

AU - Alexiou, Athanasios

AU - Soursou, Georgia

AU - Yarla, Nagendra Sastry

AU - Md Ashraf, Ghulam

PY - 2018

Y1 - 2018

N2 - Several years after the first publication of Barker's Hypothesis the identification of common patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the increasing number of diagnosed cases globally, scientists focused on commonly expressed and related proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer’s Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules that play a fundamental role in their development. These proteins are described and analyzed concerning the underlying pathology of these diseases.

AB - Several years after the first publication of Barker's Hypothesis the identification of common patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the increasing number of diagnosed cases globally, scientists focused on commonly expressed and related proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer’s Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules that play a fundamental role in their development. These proteins are described and analyzed concerning the underlying pathology of these diseases.

KW - Alzheimer’s disease

KW - Autism spectrum disorder

KW - Developmental origins of health and diseases

KW - Neurological symptoms

KW - Proteins

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DO - 10.2174/1389203718666170911145321

M3 - Review article

C2 - 28901249

AN - SCOPUS:85051418879

SN - 1389-2037

VL - 19

SP - 876

EP - 880

JO - Current Protein and Peptide Science

JF - Current Protein and Peptide Science

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Proteins commonly linked to autism spectrum disorder and Alzheimer's disease

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