Probing the glycosidic linkage: Secondary structures in the gas phase

John P. Simons, E. Cristina Stanca-Kaposta, Emilio J. Cocinero, B. Liu, Benjamin G. Davis, David P. Gamblin, Romano T. Kroemer

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
Plum Print visual indicator of research metrics
  • Citations
    • Citation Indexes: 7
  • Captures
    • Readers: 17
see details

Abstract

The functional importance of carbohydrates in biological processes, particularly those involving specific molecular recognition, is immense. Characterizing the three-dimensional (3D) structures of carbohydrates and glycoproteins, and their interactions with other molecules, not least the ubiquitous solvent, water, is a key starting point for understanding these processes. The combination of laser-based electronic and vibrational spectroscopy of mass-selected carbohydrate molecules and their hydrated complexes, conducted under molecular beam conditions, with ab initio computation is providing a uniquely powerful means of characterizing 3D carbohydrate conformations; the structures of their hydrated complexes, the hydrogen-bonded networks they support (or which support them); and the factors that determine their conformational and structural preferences.

Original languageEnglish
Article number058124
JournalPhysica Scripta
Volume78
Issue number5
DOIs
Publication statusPublished - 1 Nov 2008
Externally publishedYes

Fingerprint

Dive into the research topics of 'Probing the glycosidic linkage: Secondary structures in the gas phase'. Together they form a unique fingerprint.

Cite this

Simons, J. P., Cristina Stanca-Kaposta, E., Cocinero, E. J., Liu, B., Davis, B. G., Gamblin, D. P., & Kroemer, R. T. (2008). Probing the glycosidic linkage: Secondary structures in the gas phase. Physica Scripta, 78(5), Article 058124. https://doi.org/10.1088/0031-8949/78/05/058124