Predict two-dimensional protein folding based on hydrophobic-polar lattice model and chaotic clonal genetic algorithm

Shuihua Wang, Lenan Wu, Yuankai Huo, Xueyan Wu, Hainan Wang, Yudong Zhang*

*Corresponding author for this work

Research output: Chapter in Book or Report/Conference proceedingConference Proceedingpeer-review

6 Citations (Scopus)

Abstract

In order to improve the performance of prediction of protein folding problem, we introduce a relatively new chaotic clonal genetic algorithm (abbreviated as CCGA) to solve the 2D hydrophobic-polar lattice model. Our algorithm combines three successful components—(i) standard genetic algorithm (SGA), (ii) clonal selection algorithm (CSA), and (iii) chaotic operator. We compared this proposed CCGA with SGA, artificial immune system (AIS), and immune genetic algorithm (IGA) for various chain lengths. It demonstrated that CCGA had better performance than other methods over large-sized protein chains.

Original languageEnglish
Title of host publicationIntelligent Data Engineering and Automated Learning - 17th International Conference, IDEAL 2016, Proceedings
EditorsDaoqiang Zhang, Yang Gao, Hujun Yin, Bin Li, Yun Li, Ming Yang, Frank Klawonn, Antonio J. Tallón-Ballesteros
PublisherSpringer Verlag
Pages10-17
Number of pages8
ISBN (Print)9783319462561
DOIs
Publication statusPublished - 2016
Externally publishedYes
Event17th International Conference on Intelligent Data Engineering and Automated Learning, IDEAL 2016 - Yangzhou, China
Duration: 12 Oct 201614 Oct 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9937 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference17th International Conference on Intelligent Data Engineering and Automated Learning, IDEAL 2016
Country/TerritoryChina
CityYangzhou
Period12/10/1614/10/16

Keywords

  • Artificial immune system
  • Chaotic clonal genetic algorithm
  • Clonal selection algorithm
  • Hydrophobic-polar model
  • Protein folding

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