Phosphinic peptides as zinc metalloproteinase inhibitors

V. Dive; D. Georgiadis; M. Matziari; A. Makaritis; F. Beau; P. Cuniasse; A. Yiotakis

doi:10.1007/s00018-004-4050-y

Phosphinic peptides as zinc metalloproteinase inhibitors

V. Dive^*, D. Georgiadis, M. Matziari, A. Makaritis, F. Beau, P. Cuniasse, A. Yiotakis

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

84 Citations (Scopus)

Abstract

Solid-phase synthesis of phosphinic peptides was introduced 10 years ago. A major application of this chemistry has been the development of potent synthetic inhibitors of zinc metalloproteases. Specific properties of the inhibitors produced in recent years are reviewed, supporting the notion that phosphinic pseudo-peptides are useful tools for studying the structural and functional biology of zinc proteases.

Original language	English
Pages (from-to)	2010-2019
Number of pages	10
Journal	Cellular and Molecular Life Sciences
Volume	61
Issue number	16
DOIs	https://doi.org/10.1007/s00018-004-4050-y
Publication status	Published - 2004
Externally published	Yes

Keywords

ACE
Inhibitors
MMPs
Phosphinic
Transition-state
Zinc proteases

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10.1007/s00018-004-4050-y

Cite this

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abstract = "Solid-phase synthesis of phosphinic peptides was introduced 10 years ago. A major application of this chemistry has been the development of potent synthetic inhibitors of zinc metalloproteases. Specific properties of the inhibitors produced in recent years are reviewed, supporting the notion that phosphinic pseudo-peptides are useful tools for studying the structural and functional biology of zinc proteases.",

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AU - Georgiadis, D.

AU - Matziari, M.

AU - Makaritis, A.

AU - Beau, F.

AU - Cuniasse, P.

AU - Yiotakis, A.

PY - 2004

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AB - Solid-phase synthesis of phosphinic peptides was introduced 10 years ago. A major application of this chemistry has been the development of potent synthetic inhibitors of zinc metalloproteases. Specific properties of the inhibitors produced in recent years are reviewed, supporting the notion that phosphinic pseudo-peptides are useful tools for studying the structural and functional biology of zinc proteases.

KW - ACE

KW - Inhibitors

KW - MMPs

KW - Phosphinic

KW - Transition-state

KW - Zinc proteases

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U2 - 10.1007/s00018-004-4050-y

DO - 10.1007/s00018-004-4050-y

M3 - Review article

C2 - 15316651

AN - SCOPUS:4344573848

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VL - 61

SP - 2010

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JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 16

ER -

Phosphinic peptides as zinc metalloproteinase inhibitors

Abstract

Keywords

Access to Document

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