TY - JOUR
T1 - Phosphinic acids
T2 - current status and potential for drug discovery
AU - Abdou, Moaz M.
AU - O'Neill, Paul M.
AU - Amigues, Eric
AU - Matziari, Magdalini
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/3
Y1 - 2019/3
N2 - Phosphinic acid derivatives exhibit diverse biological activities and a high degree of structural diversity, rendering them a versatile tool in the development of new medicinal agents. Pronounced recent progress, coupled with previous research findings, highlights the impact of this moiety in medicinal chemistry. Here, we highlight the most important breakthroughs made with phosphinates with a range of pharmacological activities against many diseases, including anti-inflammatory, anti-Alzheimer, antiparasitic, antihepatitis, antiproliferative, anti-influenza, anti-HIV, antimalarial, and antimicrobial agents.
AB - Phosphinic acid derivatives exhibit diverse biological activities and a high degree of structural diversity, rendering them a versatile tool in the development of new medicinal agents. Pronounced recent progress, coupled with previous research findings, highlights the impact of this moiety in medicinal chemistry. Here, we highlight the most important breakthroughs made with phosphinates with a range of pharmacological activities against many diseases, including anti-inflammatory, anti-Alzheimer, antiparasitic, antihepatitis, antiproliferative, anti-influenza, anti-HIV, antimalarial, and antimicrobial agents.
UR - http://www.scopus.com/inward/record.url?scp=85058556336&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2018.11.016
DO - 10.1016/j.drudis.2018.11.016
M3 - Review article
C2 - 30481556
AN - SCOPUS:85058556336
SN - 1359-6446
VL - 24
SP - 916
EP - 929
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 3
ER -
