TY - JOUR
T1 - Pharmacological modulation of anxiety-related behaviors in the murine Suok test
AU - Kalueff, A. V.
AU - Keisala, T.
AU - Minasyan, A.
AU - Tuohimaa, P.
PY - 2007/9/14
Y1 - 2007/9/14
N2 - We have recently introduced a new model of anxiety - the Suok test and its light-dark modification - for behavioral characterization in mice and rats, including simultaneous assessment of their anxiety, activity, and neurological phenotypes. In the present study, testing different inbred (129S1, BALB/c) and hybrid (C57-129S1) mouse strains in both Suok test modifications, we examined the effects on anxiety-related behaviours produced by traditional anxiogenic and anxiolytic drugs. Here we show dose-dependent increases in anxiety-related behaviors produced by anxiogenic drug pentylenetetrazole (10 and 20 mg/kg). In contrast, anxiolytic drugs ethanol (0.75 and 1.5 g/kg) and diazepam (0.5 mg/kg) reduced anxiety and increased mouse exploration in this test. Hyperemotional anxious BALB/c mice were particularly sensitive to pharmacogenic anxiety in Suok test, also showing robust light-dark shifts in the light-dark version of this test. Overall, the results of this study confirm the potential utility of both murine Suok tests, especially when used in selected "sensitive" mouse strains, for high-throughput screening of potential anxiotropic drugs.
AB - We have recently introduced a new model of anxiety - the Suok test and its light-dark modification - for behavioral characterization in mice and rats, including simultaneous assessment of their anxiety, activity, and neurological phenotypes. In the present study, testing different inbred (129S1, BALB/c) and hybrid (C57-129S1) mouse strains in both Suok test modifications, we examined the effects on anxiety-related behaviours produced by traditional anxiogenic and anxiolytic drugs. Here we show dose-dependent increases in anxiety-related behaviors produced by anxiogenic drug pentylenetetrazole (10 and 20 mg/kg). In contrast, anxiolytic drugs ethanol (0.75 and 1.5 g/kg) and diazepam (0.5 mg/kg) reduced anxiety and increased mouse exploration in this test. Hyperemotional anxious BALB/c mice were particularly sensitive to pharmacogenic anxiety in Suok test, also showing robust light-dark shifts in the light-dark version of this test. Overall, the results of this study confirm the potential utility of both murine Suok tests, especially when used in selected "sensitive" mouse strains, for high-throughput screening of potential anxiotropic drugs.
KW - Anxiety
KW - Drug-evoked alterations
KW - Light-dark modification
KW - Mice
KW - Suok test
UR - http://www.scopus.com/inward/record.url?scp=34547540843&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2007.05.002
DO - 10.1016/j.brainresbull.2007.05.002
M3 - Article
C2 - 17683788
AN - SCOPUS:34547540843
SN - 0361-9230
VL - 74
SP - 45
EP - 50
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 1-3
ER -