Persistent c-fos expression and NADPH-d reactivity in the medulla and the lumbar spinal cord in rat with short-term peripheral anosmia

A. V. Kalueff*, V. A. Maisky, A. I. Pilyavskii, N. E. Makarchuk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Here we examine hypothesis that short-term peripheral ZnSO4-induced anosmia can produce effects on c-fos expression within spinal cord and caudal medulla in male Wistar rats (n = 4). Fos-like-immunoreactive cells revealed by avidin-biotin-peroxidase method show a significant bilateral increase in the nucleus proprius (layers 3 and 4) and medial part of layers 5 and 6. In substantia gelatinosa (layer 2i) and area 10 Fos-positive neurons were intermixed together with nicotin-amide adenine dineucleotide phosphate-diaphorase (NADPH-d)-reactive cells. Short-term anosmia enhanced c-fos expression in ventral horn (layers 7 and 8), ventrolateral segment and dorsal part of the spinal trigeminal nuclei. In anosmic rats varicose fibres and numerous NADPH-d-stained neurons were present in the gelatinous layer of the spinal trigeminal nucleus caudalis, and a separate population of Fos-positive cells was detected within this layer. Nucleus tractus solitaris also contained a few NADPH-d-reactive, medium sized neurons intermixed with Fos-immunoreactive cells.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalNeuroscience Letters
Volume301
Issue number2
DOIs
Publication statusPublished - 30 Mar 2001
Externally publishedYes

Keywords

  • Anosmia
  • Anxiety
  • C-fos expression
  • Grooming
  • Rat
  • Sensitization

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