Organophosphonate functionalized Gd@C82 as a magnetic resonance imaging contrast agent

Chun Ying Shu; Ghun Ru Wang; Jian Fei Zhang; Harry W. Gibson; Harry C. Dorn; Frank D. Corwin; Panos P. Fatouros; T. John S. Dennis

doi:10.1021/cm7023982

Organophosphonate functionalized Gd@C₈₂ as a magnetic resonance imaging contrast agent

Chun Ying Shu, Ghun Ru Wang^*, Jian Fei Zhang, Harry W. Gibson, Harry C. Dorn, Frank D. Corwin, Panos P. Fatouros, T. John S. Dennis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM^_1 s^_1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM^- s^-1) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C₈₂ (16.0 mM ^-1 s^-1) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.

Original language	English
Pages (from-to)	2106-2109
Number of pages	4
Journal	Chemistry of Materials
Volume	20
Issue number	6
DOIs	https://doi.org/10.1021/cm7023982
Publication status	Published - 25 Mar 2008
Externally published	Yes

Access to Document

10.1021/cm7023982

Cite this

@article{edd8865885e3492a9eb9aa0cbac75477,

title = "Organophosphonate functionalized Gd@C82 as a magnetic resonance imaging contrast agent",

abstract = "A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM_1 s_1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM- s-1) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C82 (16.0 mM -1 s-1) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.",

author = "Shu, {Chun Ying} and Wang, {Ghun Ru} and Zhang, {Jian Fei} and Gibson, {Harry W.} and Dorn, {Harry C.} and Corwin, {Frank D.} and Fatouros, {Panos P.} and Dennis, {T. John S.}",

year = "2008",

month = mar,

day = "25",

doi = "10.1021/cm7023982",

language = "English",

volume = "20",

pages = "2106--2109",

journal = "Chemistry of Materials",

issn = "0897-4756",

number = "6",

}

TY - JOUR

T1 - Organophosphonate functionalized Gd@C82 as a magnetic resonance imaging contrast agent

AU - Shu, Chun Ying

AU - Wang, Ghun Ru

AU - Zhang, Jian Fei

AU - Gibson, Harry W.

AU - Dorn, Harry C.

AU - Corwin, Frank D.

AU - Fatouros, Panos P.

AU - Dennis, T. John S.

PY - 2008/3/25

Y1 - 2008/3/25

N2 - A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM_1 s_1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM- s-1) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C82 (16.0 mM -1 s-1) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.

AB - A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM_1 s_1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM- s-1) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C82 (16.0 mM -1 s-1) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.

UR - http://www.scopus.com/inward/record.url?scp=41749124132&partnerID=8YFLogxK

U2 - 10.1021/cm7023982

DO - 10.1021/cm7023982

M3 - Article

AN - SCOPUS:41749124132

SN - 0897-4756

VL - 20

SP - 2106

EP - 2109

JO - Chemistry of Materials

JF - Chemistry of Materials

IS - 6

ER -

Organophosphonate functionalized Gd@C₈₂ as a magnetic resonance imaging contrast agent

Abstract

Access to Document

Other files and links

Fingerprint

Cite this