Optical behaviors of ZnO-porphyrin conjugates and their potential applications for cancer treatment

Yuanfang Liu; Yongbin Zhang; Shaopeng Wang; Carey Pope; Wei Chen

doi:10.1063/1.2908211

Optical behaviors of ZnO-porphyrin conjugates and their potential applications for cancer treatment

Yuanfang Liu, Yongbin Zhang, Shaopeng Wang, Carey Pope, Wei Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

ZnO nanoparticles were synthesized and conjugated to the porphyrin derivative, meso-tetra (o-amino phenyl) porphyrin (MTAP). Energy transfer from the ZnO nanoparticles to MTAP was investigated and the energy transfer rate was measured to be as high as 83%. Compared with MTAP and ZnO alone, ZnO-MTAP conjugates have low toxicity under dark conditions but high phototoxicity in the human ovarian carcinoma cell line NIH:OVCAR-3. The results indicate that ZnO-MTAP conjugates may be useful in photodynamic therapy for deep cancer treatment.

Original language	English
Article number	143901
Journal	Applied Physics Letters
Volume	92
Issue number	14
DOIs	https://doi.org/10.1063/1.2908211
Publication status	Published - 2008
Externally published	Yes

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10.1063/1.2908211

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title = "Optical behaviors of ZnO-porphyrin conjugates and their potential applications for cancer treatment",

abstract = "ZnO nanoparticles were synthesized and conjugated to the porphyrin derivative, meso-tetra (o-amino phenyl) porphyrin (MTAP). Energy transfer from the ZnO nanoparticles to MTAP was investigated and the energy transfer rate was measured to be as high as 83%. Compared with MTAP and ZnO alone, ZnO-MTAP conjugates have low toxicity under dark conditions but high phototoxicity in the human ovarian carcinoma cell line NIH:OVCAR-3. The results indicate that ZnO-MTAP conjugates may be useful in photodynamic therapy for deep cancer treatment.",

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AU - Liu, Yuanfang

AU - Zhang, Yongbin

AU - Wang, Shaopeng

AU - Pope, Carey

AU - Chen, Wei

PY - 2008

Y1 - 2008

N2 - ZnO nanoparticles were synthesized and conjugated to the porphyrin derivative, meso-tetra (o-amino phenyl) porphyrin (MTAP). Energy transfer from the ZnO nanoparticles to MTAP was investigated and the energy transfer rate was measured to be as high as 83%. Compared with MTAP and ZnO alone, ZnO-MTAP conjugates have low toxicity under dark conditions but high phototoxicity in the human ovarian carcinoma cell line NIH:OVCAR-3. The results indicate that ZnO-MTAP conjugates may be useful in photodynamic therapy for deep cancer treatment.

AB - ZnO nanoparticles were synthesized and conjugated to the porphyrin derivative, meso-tetra (o-amino phenyl) porphyrin (MTAP). Energy transfer from the ZnO nanoparticles to MTAP was investigated and the energy transfer rate was measured to be as high as 83%. Compared with MTAP and ZnO alone, ZnO-MTAP conjugates have low toxicity under dark conditions but high phototoxicity in the human ovarian carcinoma cell line NIH:OVCAR-3. The results indicate that ZnO-MTAP conjugates may be useful in photodynamic therapy for deep cancer treatment.

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DO - 10.1063/1.2908211

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VL - 92

JO - Applied Physics Letters

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IS - 14

M1 - 143901

ER -

Optical behaviors of ZnO-porphyrin conjugates and their potential applications for cancer treatment

Abstract

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