TY - JOUR
T1 - New anticancer agents
T2 - Recent developments in tumor therapy
AU - Ali, Riyasat
AU - Mirza, Zeenat
AU - Ashraf, Ghulam M.D.
AU - Kamal, Mohammad Amjad
AU - Ansari, Shakeel Ahmed
AU - Damanhouri, Ghazi Abdullah
AU - Abuzenadah, Adel Mohammad
AU - Chaudhary, Adeel Ga
AU - Sheikh, Ishfaq Ahmed
PY - 2012/7
Y1 - 2012/7
N2 - Increasing recurrence of mammalian tumors and severe side-effects of chemotherapeutic agents reduce the clinical efficacy of a large variety of anticancer agents that are currently being used. Thus, there is always a constant need to develop alternative or synergistic anticancer drugs with minimal side-effects. One important strategy to develop effective anticancer agents is to study into anticancer agents derived from natural sources. Anticancer agents derived from plants and their derivatives have been proven to be effective for cancer prevention and therapeutics. Vinca alkaloid and their derivatives, alone and in combination with therapeutic agents, have been used for a long time for the treatment of various types of cancers. Polyphenols form one of the most important and extensively used classes of plant-derived therapeutics for cancer prevention or chemotherapy. The present review highlights a plethora of studies focused on the antineoplastic properties of plant-derived chemicals, such as Vinca alkaloid, saponins, and flavonoids.
AB - Increasing recurrence of mammalian tumors and severe side-effects of chemotherapeutic agents reduce the clinical efficacy of a large variety of anticancer agents that are currently being used. Thus, there is always a constant need to develop alternative or synergistic anticancer drugs with minimal side-effects. One important strategy to develop effective anticancer agents is to study into anticancer agents derived from natural sources. Anticancer agents derived from plants and their derivatives have been proven to be effective for cancer prevention and therapeutics. Vinca alkaloid and their derivatives, alone and in combination with therapeutic agents, have been used for a long time for the treatment of various types of cancers. Polyphenols form one of the most important and extensively used classes of plant-derived therapeutics for cancer prevention or chemotherapy. The present review highlights a plethora of studies focused on the antineoplastic properties of plant-derived chemicals, such as Vinca alkaloid, saponins, and flavonoids.
KW - Natural products
KW - New anticancer agents
KW - Plant-derived chemicals
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=84865682929&partnerID=8YFLogxK
M3 - Review article
C2 - 22753764
AN - SCOPUS:84865682929
SN - 0250-7005
VL - 32
SP - 2999
EP - 3005
JO - Anticancer Research
JF - Anticancer Research
IS - 7
ER -
