TY - JOUR
T1 - Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology
AU - Stewart, Adam
AU - Wong, Keith
AU - Cachat, Jonathan
AU - Elegante, Marco
AU - Gilder, Tom
AU - Mohnot, Sopan
AU - Wu, Nadine
AU - Minasyan, Anna
AU - Tuohimaa, Pentti
AU - Kalueff, Allan V.
PY - 2010/9
Y1 - 2010/9
N2 - Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.
AB - Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.
KW - genetic polymorphisms
KW - hypovitaminosis D
KW - mutant mouse models
KW - neurobehavioral disorders
KW - vitamin D
KW - vitamin D receptor
UR - http://www.scopus.com/inward/record.url?scp=77955983257&partnerID=8YFLogxK
U2 - 10.1097/FBP.0b013e32833c850f
DO - 10.1097/FBP.0b013e32833c850f
M3 - Review article
C2 - 20571365
AN - SCOPUS:77955983257
SN - 0955-8810
VL - 21
SP - 420
EP - 426
JO - Behavioural Pharmacology
JF - Behavioural Pharmacology
IS - 5-6
ER -
