Abstract
PURPOSE OF REVIEW: Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. We discuss clinical and experimental evidence of the role of vitamin D in normal and pathological brain functions, and analyze the relative importance of vitamin D-modulated brain mechanisms at different stages of life. We also outline perspectives for the use of vitamin D in clinical nutrition to prevent or treat various brain disorders. RECENT FINDINGS: Numerous brain dysfunctions are linked to vitamin D deficits and/or dysfunctions of its receptors. In both animals and humans, vitamin D serves as an important endogenous and/or exogenous regulator of neuroprotection, antiepileptic and anticalcification effects, neuro-immunomodulation, interplay with neurotransmitters and hormones, modulation of behaviors, brain ageing, and some other, less-explored, brain processes. SUMMARY: Vitamin D emerges as an important neurosteroid hormone in the brain, with a strong potential for age-specific applications in clinical nutrition.
Original language | English |
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Pages (from-to) | 12-19 |
Number of pages | 8 |
Journal | Current Opinion in Clinical Nutrition and Metabolic Care |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2007 |
Externally published | Yes |
Keywords
- Neurosteroid hormone
- Supplementation and therapy
- Vitamin D