TY - JOUR
T1 - NeuroMuscleDB
T2 - a Database of Genes Associated with Muscle Development, Neuromuscular Diseases, Ageing, and Neurodegeneration
AU - Baig, Mohammad Hassan
AU - Rashid, Iliyas
AU - Srivastava, Prachi
AU - Ahmad, Khurshid
AU - Jan, Arif Tasleem
AU - Rabbani, Gulam
AU - Choi, Dukhwan
AU - Barreto, George E.
AU - Ashraf, Ghulam Md
AU - Lee, Eun Ju
AU - Choi, Inho
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Skeletal muscle is a highly complex, heterogeneous tissue that serves a multitude of biological functions in living organisms. With the advent of methods, such as microarrays, transcriptome analysis, and proteomics, studies have been performed at the genome level to gain insight of changes in the expression profiles of genes during different stages of muscle development and of associated diseases. In the present study, a database was conceived for the straightforward retrieval of information on genes involved in skeletal muscle formation, neuromuscular diseases (NMDs), ageing, and neurodegenerative disorders (NDs). The resulting database named NeuroMuscleDB (http://yu-mbl-muscledb.com/NeuroMuscleDB) is the result of a wide literature survey, database searches, and data curation. NeuroMuscleDB contains information of genes in Homo sapiens, Mus musculus, and Bos Taurus, and their promoter sequences and specified roles at different stages of muscle development and in associated myopathies. The database contains information on ~ 1102 genes, 6030 mRNAs, and 5687 proteins, and embedded analytical tools that can be used to perform tasks related to gene sequence usage. The authors believe NeuroMuscleDB provides a platform for obtaining desired information on genes related to myogenesis and their associations with various diseases (NMDs, ageing, and NDs). NeuroMuscleDB is freely available on the web at http://yu-mbl-muscledb.com/NeuroMuscleDB and supports all major browsers.
AB - Skeletal muscle is a highly complex, heterogeneous tissue that serves a multitude of biological functions in living organisms. With the advent of methods, such as microarrays, transcriptome analysis, and proteomics, studies have been performed at the genome level to gain insight of changes in the expression profiles of genes during different stages of muscle development and of associated diseases. In the present study, a database was conceived for the straightforward retrieval of information on genes involved in skeletal muscle formation, neuromuscular diseases (NMDs), ageing, and neurodegenerative disorders (NDs). The resulting database named NeuroMuscleDB (http://yu-mbl-muscledb.com/NeuroMuscleDB) is the result of a wide literature survey, database searches, and data curation. NeuroMuscleDB contains information of genes in Homo sapiens, Mus musculus, and Bos Taurus, and their promoter sequences and specified roles at different stages of muscle development and in associated myopathies. The database contains information on ~ 1102 genes, 6030 mRNAs, and 5687 proteins, and embedded analytical tools that can be used to perform tasks related to gene sequence usage. The authors believe NeuroMuscleDB provides a platform for obtaining desired information on genes related to myogenesis and their associations with various diseases (NMDs, ageing, and NDs). NeuroMuscleDB is freely available on the web at http://yu-mbl-muscledb.com/NeuroMuscleDB and supports all major browsers.
KW - Ageing
KW - Database
KW - Genes
KW - Myogenesis
KW - Neurodegenerative disorders
KW - Neuromuscular dystrophies
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85060690756&partnerID=8YFLogxK
U2 - 10.1007/s12035-019-1478-5
DO - 10.1007/s12035-019-1478-5
M3 - Article
C2 - 30684219
AN - SCOPUS:85060690756
SN - 0893-7648
VL - 56
SP - 5835
EP - 5843
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 8
ER -