TY - CHAP
T1 - Modulation of Different Signaling Pathways in Liver Cancer by Arsenic Trioxide
AU - Chaudhary, Archana
AU - Ashraf, Ghulam Mohammad
AU - Ahmad, Md Margoob
AU - Kumar, Manish
AU - Haque, Rizwanul
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - The greatest health concern facing the globe today is still cancer. In order to defeat various malignancies, researchers are now racing to develop effective anticancer tactics to stop this global tidal wave of cancer in both its extremely early and advanced stages. However, very few specific treatments or medications have so far been proven to be effective. An old medication called arsenic trioxide (As2O3) has recently gained resurgence as a treatment for several cancers. Arsenic is generally recognized as a naturally hazardous material that can cause a wide range of harmful adverse reactions. Despite its present image as a poison, arsenic is one of the world’s oldest medicines and has been used for ages to treat conditions ranging from cancer to infections. Due to its treatable antitumor impact in acute promyelocyticleukaemia (APL) patients, it attracted a lot of attention from people worldwide. The anticancer medication most frequently used among the arsenicals is (ATO) arsenic trioxide. Numerous studies have been carried out to comprehend the molecular pathways through which ATO induces or facilitates the apoptotic signalling pathway in cancer cells. The treatment of Hepatocellular Carcinoma (HCC) and other cancers with novel, currently available arsenic-based therapeutics is discussed here. We also discussed the novel molecular mechanism that underlies the combined therapy’ induction of apoptosis.
AB - The greatest health concern facing the globe today is still cancer. In order to defeat various malignancies, researchers are now racing to develop effective anticancer tactics to stop this global tidal wave of cancer in both its extremely early and advanced stages. However, very few specific treatments or medications have so far been proven to be effective. An old medication called arsenic trioxide (As2O3) has recently gained resurgence as a treatment for several cancers. Arsenic is generally recognized as a naturally hazardous material that can cause a wide range of harmful adverse reactions. Despite its present image as a poison, arsenic is one of the world’s oldest medicines and has been used for ages to treat conditions ranging from cancer to infections. Due to its treatable antitumor impact in acute promyelocyticleukaemia (APL) patients, it attracted a lot of attention from people worldwide. The anticancer medication most frequently used among the arsenicals is (ATO) arsenic trioxide. Numerous studies have been carried out to comprehend the molecular pathways through which ATO induces or facilitates the apoptotic signalling pathway in cancer cells. The treatment of Hepatocellular Carcinoma (HCC) and other cancers with novel, currently available arsenic-based therapeutics is discussed here. We also discussed the novel molecular mechanism that underlies the combined therapy’ induction of apoptosis.
KW - Apoptosis
KW - Arsenic trioxide (ATO)
KW - Cellular signaling pathways
KW - Hepatocellular carcinoma (HCC)
UR - http://www.scopus.com/inward/record.url?scp=85169705708&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-37561-3_4
DO - 10.1007/978-3-031-37561-3_4
M3 - Chapter
AN - SCOPUS:85169705708
T3 - Environmental Science and Engineering
SP - 61
EP - 84
BT - Environmental Science and Engineering
PB - Springer Science and Business Media Deutschland GmbH
ER -
