Modeling mouse anxiety and sensorimotor integration: Neurobehavioral phenotypes in the suok test

Elisabeth Dow; Valerie Piet; Adam Stewart; Siddharth Gaikwad; Jonathan Cachat; Peter Hart; Nadine Wu; Evan Kyzar; Eli Utterback; Alan Newman; Molly Hook; Kathryn Rhymes; Dillon Carlos; Allan V. Kalueff

doi:10.1007/978-1-61779-313-4_4

Modeling mouse anxiety and sensorimotor integration: Neurobehavioral phenotypes in the suok test

Elisabeth Dow^*, Valerie Piet, Adam Stewart, Siddharth Gaikwad, Jonathan Cachat, Peter Hart, Nadine Wu, Evan Kyzar, Eli Utterback, Alan Newman, Molly Hook, Kathryn Rhymes, Dillon Carlos, Allan V. Kalueff

^*Corresponding author for this work

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

Abstract

Animal behavioral tests are useful tools for modeling complex human brain disorders. The Suok test (ST) is a relatively new behavioral paradigm that simultaneously examines anxiety and neurological/vestibular phenotypes in rodents. The novelty and instability of the ST apparatus induces anxiety-related behavior in mice, whereas the elevation of the horizontal rod allows for the assessment of motor and neurological phenotypes. This chapter discusses the utility of the ST in detecting mouse anxiety, habituation, exploration, motorisensory deficits, and the interplay between these domains. With a growing number of laboratories using this model, a detailed protocol for the ST behavioral analysis (with a focus on video-tracking tools and novel applications) is also provided.

Original language	English
Title of host publication	Mood and Anxiety Related Phenotypes in Mice
Subtitle of host publication	Characterization Using Behavioral Tests, Volume II
Editors	Todd Gould
Pages	61-81
Number of pages	21
DOIs	https://doi.org/10.1007/978-1-61779-313-4_4
Publication status	Published - 2011
Externally published	Yes

Publication series

Name	Neuromethods
Volume	63
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Keywords

Anxiety
Behavioral models
Ethological analysis
Exploration
Mice
Stress
Stress-evoked sensorimotor disintegration
Vestibular phenotypes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-61779-313-4_4

Cite this

Dow, E., Piet, V., Stewart, A., Gaikwad, S., Cachat, J., Hart, P., Wu, N., Kyzar, E., Utterback, E., Newman, A., Hook, M., Rhymes, K., Carlos, D., & Kalueff, A. V. (2011). Modeling mouse anxiety and sensorimotor integration: Neurobehavioral phenotypes in the suok test. In T. Gould (Ed.), Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II (pp. 61-81). (Neuromethods; Vol. 63). https://doi.org/10.1007/978-1-61779-313-4_4

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abstract = "Animal behavioral tests are useful tools for modeling complex human brain disorders. The Suok test (ST) is a relatively new behavioral paradigm that simultaneously examines anxiety and neurological/vestibular phenotypes in rodents. The novelty and instability of the ST apparatus induces anxiety-related behavior in mice, whereas the elevation of the horizontal rod allows for the assessment of motor and neurological phenotypes. This chapter discusses the utility of the ST in detecting mouse anxiety, habituation, exploration, motorisensory deficits, and the interplay between these domains. With a growing number of laboratories using this model, a detailed protocol for the ST behavioral analysis (with a focus on video-tracking tools and novel applications) is also provided.",

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author = "Elisabeth Dow and Valerie Piet and Adam Stewart and Siddharth Gaikwad and Jonathan Cachat and Peter Hart and Nadine Wu and Evan Kyzar and Eli Utterback and Alan Newman and Molly Hook and Kathryn Rhymes and Dillon Carlos and Kalueff, {Allan V.}",

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Dow, E, Piet, V, Stewart, A, Gaikwad, S, Cachat, J, Hart, P, Wu, N, Kyzar, E, Utterback, E, Newman, A, Hook, M, Rhymes, K, Carlos, D & Kalueff, AV 2011, Modeling mouse anxiety and sensorimotor integration: Neurobehavioral phenotypes in the suok test. in T Gould (ed.), Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II. Neuromethods, vol. 63, pp. 61-81. https://doi.org/10.1007/978-1-61779-313-4_4

Modeling mouse anxiety and sensorimotor integration: Neurobehavioral phenotypes in the suok test. / Dow, Elisabeth; Piet, Valerie; Stewart, Adam et al.
Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II. ed. / Todd Gould. 2011. p. 61-81 (Neuromethods; Vol. 63).

Research output: Chapter in Book or Report/Conference proceeding › Chapter › peer-review

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AU - Wu, Nadine

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Modeling mouse anxiety and sensorimotor integration: Neurobehavioral phenotypes in the suok test

Abstract

Publication series

Keywords

UN SDGs

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