Modeling and assaying seizure activity in zebrafish (Danio rerio)

David S. Galstyan; Tatyana O. Kolesnikova; Yurii M. Kositsyn; Konstantin N. Zabegalov; Mariya A. Gubaidullina; Gleb O. Maslov; Konstantin A. Demin; Allan V. Kalueff

doi:10.17816/RCF202193-199

Modeling and assaying seizure activity in zebrafish (Danio rerio)

David S. Galstyan, Tatyana O. Kolesnikova, Yurii M. Kositsyn, Konstantin N. Zabegalov, Mariya A. Gubaidullina, Gleb O. Maslov, Konstantin A. Demin, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.

Original language	English
Pages (from-to)	193-199
Number of pages	7
Journal	Reviews on Clinical Pharmacology and Drug Therapy
Volume	20
Issue number	2
DOIs	https://doi.org/10.17816/RCF202193-199
Publication status	Published - 2022
Externally published	Yes

Keywords

epilepsy
hyperactivity
seizures
strychnine
zebrafish

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10.17816/RCF202193-199

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title = "Modeling and assaying seizure activity in zebrafish (Danio rerio)",

abstract = "Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.",

keywords = "epilepsy, hyperactivity, seizures, strychnine, zebrafish",

author = "Galstyan, {David S.} and Kolesnikova, {Tatyana O.} and Kositsyn, {Yurii M.} and Zabegalov, {Konstantin N.} and Gubaidullina, {Mariya A.} and Maslov, {Gleb O.} and Demin, {Konstantin A.} and Kalueff, {Allan V.}",

note = "Publisher Copyright: {\textcopyright} Eco-Vector, 2022.",

year = "2022",

doi = "10.17816/RCF202193-199",

language = "English",

volume = "20",

pages = "193--199",

journal = "Reviews on Clinical Pharmacology and Drug Therapy",

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T1 - Modeling and assaying seizure activity in zebrafish (Danio rerio)

AU - Galstyan, David S.

AU - Kolesnikova, Tatyana O.

AU - Kositsyn, Yurii M.

AU - Zabegalov, Konstantin N.

AU - Gubaidullina, Mariya A.

AU - Maslov, Gleb O.

AU - Demin, Konstantin A.

AU - Kalueff, Allan V.

N1 - Publisher Copyright: © Eco-Vector, 2022.

PY - 2022

Y1 - 2022

N2 - Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.

AB - Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.

KW - epilepsy

KW - hyperactivity

KW - seizures

KW - strychnine

KW - zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85166744597&partnerID=8YFLogxK

U2 - 10.17816/RCF202193-199

DO - 10.17816/RCF202193-199

M3 - Article

AN - SCOPUS:85166744597

SN - 1683-4100

VL - 20

SP - 193

EP - 199

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

IS - 2

ER -

Modeling and assaying seizure activity in zebrafish (Danio rerio)

Abstract

Keywords

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