TY - JOUR
T1 - Lysophosphatidic acid and its receptors
T2 - pharmacology and therapeutic potential in atherosclerosis and vascular disease
AU - Zhou, Ying
AU - Little, Peter J.
AU - Ta, Hang T.
AU - Xu, Suowen
AU - Kamato, Danielle
N1 - Publisher Copyright:
© 2019
PY - 2019/12
Y1 - 2019/12
N2 - Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological responses, contributing to inflammation, thrombosis and atherosclerosis. There have recently been considerable advances in GPCR signaling especially recognition of the extended role for GPCR transactivation of tyrosine and serine/threonine kinase growth factor receptors. This review covers LPA signaling pathways in the light of new information. The use of transgenic and gene knockout animals, gene manipulated cells, pharmacological LPA receptor agonists and antagonists have provided many insights into the biological significance of LPA and individual LPA receptors in the progression of atherosclerosis and vascular diseases. This review provides a comprehensive presentation of LPA with the highlight of the distinct role of its receptors in cell and animal models that relate to atherosclerosis and vascular diseases, and therefore provides new opportunities to reduce the burden of cardiovascular diseases. The recent drug development strategies that target LPA signaling pathways are also included in this review.
AB - Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological responses, contributing to inflammation, thrombosis and atherosclerosis. There have recently been considerable advances in GPCR signaling especially recognition of the extended role for GPCR transactivation of tyrosine and serine/threonine kinase growth factor receptors. This review covers LPA signaling pathways in the light of new information. The use of transgenic and gene knockout animals, gene manipulated cells, pharmacological LPA receptor agonists and antagonists have provided many insights into the biological significance of LPA and individual LPA receptors in the progression of atherosclerosis and vascular diseases. This review provides a comprehensive presentation of LPA with the highlight of the distinct role of its receptors in cell and animal models that relate to atherosclerosis and vascular diseases, and therefore provides new opportunities to reduce the burden of cardiovascular diseases. The recent drug development strategies that target LPA signaling pathways are also included in this review.
KW - Atherosclerosis
KW - G proteins
KW - G-protein coupled receptors
KW - Lysophosphatidic acid
KW - Transactivation
KW - β-arrestins
UR - http://www.scopus.com/inward/record.url?scp=85071671878&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2019.107404
DO - 10.1016/j.pharmthera.2019.107404
M3 - Review article
C2 - 31472182
AN - SCOPUS:85071671878
SN - 0163-7258
VL - 204
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
M1 - 107404
ER -
