TY - JOUR
T1 - Local field enhanced Au/CuS nanocomposites as efficient photothermal transducer agents for cancer treatment
AU - Lakshmanan, Santana Bala
AU - Zou, Xiaoju
AU - Hossu, Marius
AU - Ma, Lun
AU - Yang, Chang
AU - Chen, Wei
PY - 2012/12
Y1 - 2012/12
N2 - Photothermal therapy (PTT) for cancer treatment is the use of heat between 41°C and 45°C to damage cancer cells. As a new type of transducer agent for PPT of cancer, CuS nanoparticles have several advantages over gold nanostructures. The most favorable features are the low cost, simple and easy preparation, and small size for targeting. However, the CuS nanoparticle PTT efficacy needs to be improved for practical applications. In this study, the CuS nano-PTT efficiency was enhanced via the local field enhancement from Au nanoparticle surface plasmon coupling. The results show that absorbance of CuS nanoparticles in Au/CuS nanocomposites is enhanced about 2.2 times by Au nanoparticle surface plasmon coupling. Consequently, the PTT efficacy is enhanced and a power of 0.2 W/cm 2 with a 980 nm laser was sufficient for Au/CuS nano-PTT activation. We have demonstrated for the first time that surface plasmon coupling can be used to enhance CuS nanoparticle PTT for cancer treatment.
AB - Photothermal therapy (PTT) for cancer treatment is the use of heat between 41°C and 45°C to damage cancer cells. As a new type of transducer agent for PPT of cancer, CuS nanoparticles have several advantages over gold nanostructures. The most favorable features are the low cost, simple and easy preparation, and small size for targeting. However, the CuS nanoparticle PTT efficacy needs to be improved for practical applications. In this study, the CuS nano-PTT efficiency was enhanced via the local field enhancement from Au nanoparticle surface plasmon coupling. The results show that absorbance of CuS nanoparticles in Au/CuS nanocomposites is enhanced about 2.2 times by Au nanoparticle surface plasmon coupling. Consequently, the PTT efficacy is enhanced and a power of 0.2 W/cm 2 with a 980 nm laser was sufficient for Au/CuS nano-PTT activation. We have demonstrated for the first time that surface plasmon coupling can be used to enhance CuS nanoparticle PTT for cancer treatment.
KW - Au/CuS nanocomposites
KW - Cancer treatment
KW - CuS nanoparticles
KW - Local field enhancement
KW - Photothermal therapy
KW - Surface plasmon
UR - http://www.scopus.com/inward/record.url?scp=84865324065&partnerID=8YFLogxK
U2 - 10.1166/jbn.2012.1486
DO - 10.1166/jbn.2012.1486
M3 - Article
C2 - 23029996
AN - SCOPUS:84865324065
SN - 1550-7033
VL - 8
SP - 883
EP - 890
JO - Journal of Biomedical Nanotechnology
JF - Journal of Biomedical Nanotechnology
IS - 6
ER -
