TY - JOUR
T1 - Legal aspects of zebrafish neuropharmacology and neurotoxicology research
AU - de Abreu, Murilo S.
AU - Giacomini, Ana C.V.V.
AU - Echevarria, David J.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/2
Y1 - 2019/2
N2 - Despite the growing emphasis on translational neuropharmacology and drug discovery research, the legality underlying these fields are seldom considered. The zebrafish (Danio rerio) is an increasingly utilized model organism in neuropharmacology and neurotoxicology. As the acceptance of zebrafish in biomedicine continues to grow, the legal aspects of their applications remain outpaced by this exponential growth. Therefore, there is a need to evaluate the legal aspects of zebrafish applications to CNS drug research. Here, we discuss a wide range of regulatory topics relevant to zebrafish research, such as the bioethics of experimentation (including studies of stress and pain), welfare protection laws, the recent advances in CNS drug discovery, and specific legal aspects of controlled substance research in this aquatic species. The conceptualization and understanding of the zebrafish welfare and its promise as a model in toxicology can also potentially shape environmental protection practices and inform policy making.
AB - Despite the growing emphasis on translational neuropharmacology and drug discovery research, the legality underlying these fields are seldom considered. The zebrafish (Danio rerio) is an increasingly utilized model organism in neuropharmacology and neurotoxicology. As the acceptance of zebrafish in biomedicine continues to grow, the legal aspects of their applications remain outpaced by this exponential growth. Therefore, there is a need to evaluate the legal aspects of zebrafish applications to CNS drug research. Here, we discuss a wide range of regulatory topics relevant to zebrafish research, such as the bioethics of experimentation (including studies of stress and pain), welfare protection laws, the recent advances in CNS drug discovery, and specific legal aspects of controlled substance research in this aquatic species. The conceptualization and understanding of the zebrafish welfare and its promise as a model in toxicology can also potentially shape environmental protection practices and inform policy making.
KW - 3Rs
KW - Animal welfare regulations
KW - Pharmacology
KW - Toxicology
UR - http://www.scopus.com/inward/record.url?scp=85056826909&partnerID=8YFLogxK
U2 - 10.1016/j.yrtph.2018.11.007
DO - 10.1016/j.yrtph.2018.11.007
M3 - Review article
C2 - 30453007
AN - SCOPUS:85056826909
SN - 0273-2300
VL - 101
SP - 65
EP - 70
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
ER -