Latex carrier for improving protoporphyrin IX for photodynamic therapy

Brian Bui; Li Liu; Wei Chen

doi:10.1016/j.pdpdt.2016.03.007

Latex carrier for improving protoporphyrin IX for photodynamic therapy

Brian Bui^*, Li Liu, Wei Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.

Original language	English
Pages (from-to)	159-165
Number of pages	7
Journal	Photodiagnosis and Photodynamic Therapy
Volume	14
DOIs	https://doi.org/10.1016/j.pdpdt.2016.03.007
Publication status	Published - 1 Jun 2016
Externally published	Yes

Keywords

Latex carrier
Photodynamic therapy (PDT)
Protoporphyrin (PPIX)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pdpdt.2016.03.007

Cite this

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title = "Latex carrier for improving protoporphyrin IX for photodynamic therapy",

abstract = "Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.",

keywords = "Latex carrier, Photodynamic therapy (PDT), Protoporphyrin (PPIX)",

author = "Brian Bui and Li Liu and Wei Chen",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.pdpdt.2016.03.007",

language = "English",

volume = "14",

pages = "159--165",

journal = "Photodiagnosis and Photodynamic Therapy",

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T1 - Latex carrier for improving protoporphyrin IX for photodynamic therapy

AU - Bui, Brian

AU - Liu, Li

AU - Chen, Wei

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.

AB - Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.

KW - Latex carrier

KW - Photodynamic therapy (PDT)

KW - Protoporphyrin (PPIX)

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U2 - 10.1016/j.pdpdt.2016.03.007

DO - 10.1016/j.pdpdt.2016.03.007

M3 - Article

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AN - SCOPUS:84964430260

SN - 1572-1000

VL - 14

SP - 159

EP - 165

JO - Photodiagnosis and Photodynamic Therapy

JF - Photodiagnosis and Photodynamic Therapy

ER -

Latex carrier for improving protoporphyrin IX for photodynamic therapy

Abstract

Keywords

UN SDGs

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