TY - JOUR
T1 - Late-life depression and alzheimer disease
T2 - A potential synergy of the underlying mechanisms
AU - Leszek, Jerzy
AU - Trypka, Elżbieta
AU - Koutsouraki, Euphrosyni
AU - Michmizos, Dimitrios
AU - Yarla, Nagendra Sastry
AU - Tarasov, Vadim V.
AU - Ashraf, Ghulam Md
AU - Aliev, Gjumrakch
N1 - Publisher Copyright:
© 2018 Bentham Science Publishers.
PY - 2018
Y1 - 2018
N2 - A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.
AB - A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.
KW - Aging
KW - Alzheimer disease
KW - Bdnf
KW - Dementia
KW - Depression
UR - http://www.scopus.com/inward/record.url?scp=85059512747&partnerID=8YFLogxK
U2 - 10.2174/0929867323666160902152829
DO - 10.2174/0929867323666160902152829
M3 - Review article
C2 - 27593962
AN - SCOPUS:85059512747
SN - 0929-8673
VL - 25
SP - 5389
EP - 5394
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 39
ER -