Intraperitoneal injection as a method of psychotropic drug delivery in adult zebrafish

Adam Stewart, Jonathan M. Cachat, Christopher Suciu, Peter C. Hart, Siddharth Gaikwad, Eli Utterback, John Dileo, Allan V. Kalueff

Research output: Chapter in Book or Report/Conference proceedingChapterpeer-review

18 Citations (Scopus)

Abstract

Zebrafish behavioral phenotypes are often evaluated in response to pharmacological modulation by various psychotropic drugs. An important step in this process is the method of drug administration. While the most popular drug administration technique in zebrafish research is by immersion, systemic intraperitoneal injection is another effective alternative. This method is useful for drugs that are difficult to dissolve in water, or which require a better control over the amount of drug delivered to an individual animal. Here we outline a simple protocol for the intraperitoneal injection of drugs in adult zebrafish.

Original languageEnglish
Title of host publicationZebrafish Neurobehavioral Protocols
EditorsAllan Kalueff, Jonathan Cachat
Pages169-179
Number of pages11
DOIs
Publication statusPublished - 2011
Externally publishedYes

Publication series

NameNeuromethods
Volume51
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • anxiety
  • drug administration method
  • drug exposure
  • intraperitoneal injection
  • Zebrafish

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