Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis

Yixue Qiao; Kaushik Maiti; Zakia Sultana; Lei Fu; Roger Smith

doi:10.1016/j.ejmech.2019.111948

Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis

Yixue Qiao, Kaushik Maiti, Zakia Sultana, Lei Fu^*, Roger Smith

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.

Original language	English
Article number	111948
Journal	European Journal of Medicinal Chemistry
Volume	187
DOIs	https://doi.org/10.1016/j.ejmech.2019.111948
Publication status	Published - 1 Feb 2020
Externally published	Yes

Keywords

AOX inhibition
Aldehyde oxidase
Drug metabolism
Evolution
Physiology
Polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2019.111948

Cite this

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title = "Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis",

abstract = "The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.",

keywords = "AOX inhibition, Aldehyde oxidase, Drug metabolism, Evolution, Physiology, Polymorphism",

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doi = "10.1016/j.ejmech.2019.111948",

language = "English",

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T1 - Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis

AU - Qiao, Yixue

AU - Maiti, Kaushik

AU - Sultana, Zakia

AU - Fu, Lei

AU - Smith, Roger

PY - 2020/2/1

Y1 - 2020/2/1

N2 - The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.

AB - The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.

KW - AOX inhibition

KW - Aldehyde oxidase

KW - Drug metabolism

KW - Evolution

KW - Physiology

KW - Polymorphism

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U2 - 10.1016/j.ejmech.2019.111948

DO - 10.1016/j.ejmech.2019.111948

M3 - Review article

C2 - 31877540

AN - SCOPUS:85076686870

SN - 0223-5234

VL - 187

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 111948

ER -

Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis

Abstract

Keywords

UN SDGs

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