Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene

Allan V. Kalueff; Anna Minasyan; Tiina Keisala; Marianne Kuuslahti; Susanna Miettinen; Pentti Tuohimaa

doi:10.1016/j.neulet.2005.10.007

Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene

Allan V. Kalueff^*, Anna Minasyan, Tiina Keisala, Marianne Kuuslahti, Susanna Miettinen, Pentti Tuohimaa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Vitamin D is a neuroactive steroid hormone with multiple functions in the brain. Numerous clinical and experimental data link various Vitamin D-related dysfunctions to epilepsy. Here, we study the role of Vitamin D receptors (VDRs) in experimental epilepsy in mice. To examine this problem, we assessed the seizure profiles in VDR knockout mice following a systemic injection of pentylenetetrazole (70 mg/kg). Overall, compared to the wild-type (WT) 129S1 mice (n = 10 in each group), the VDR knockout group significantly demonstrated shorter latencies to the onset, higher Racine scores and increased mortality rates. Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy.

Original language	English
Pages (from-to)	69-73
Number of pages	5
Journal	Neuroscience Letters
Volume	394
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2005.10.007
Publication status	Published - 6 Feb 2006
Externally published	Yes

Keywords

Chemically induced seizures
Epilepsy
Knockout mice
Vitamin D
Vitamin D receptors

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10.1016/j.neulet.2005.10.007

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title = "Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene",

abstract = "Vitamin D is a neuroactive steroid hormone with multiple functions in the brain. Numerous clinical and experimental data link various Vitamin D-related dysfunctions to epilepsy. Here, we study the role of Vitamin D receptors (VDRs) in experimental epilepsy in mice. To examine this problem, we assessed the seizure profiles in VDR knockout mice following a systemic injection of pentylenetetrazole (70 mg/kg). Overall, compared to the wild-type (WT) 129S1 mice (n = 10 in each group), the VDR knockout group significantly demonstrated shorter latencies to the onset, higher Racine scores and increased mortality rates. Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy.",

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T1 - Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene

AU - Kalueff, Allan V.

AU - Minasyan, Anna

AU - Keisala, Tiina

AU - Kuuslahti, Marianne

AU - Miettinen, Susanna

AU - Tuohimaa, Pentti

PY - 2006/2/6

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N2 - Vitamin D is a neuroactive steroid hormone with multiple functions in the brain. Numerous clinical and experimental data link various Vitamin D-related dysfunctions to epilepsy. Here, we study the role of Vitamin D receptors (VDRs) in experimental epilepsy in mice. To examine this problem, we assessed the seizure profiles in VDR knockout mice following a systemic injection of pentylenetetrazole (70 mg/kg). Overall, compared to the wild-type (WT) 129S1 mice (n = 10 in each group), the VDR knockout group significantly demonstrated shorter latencies to the onset, higher Racine scores and increased mortality rates. Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy.

AB - Vitamin D is a neuroactive steroid hormone with multiple functions in the brain. Numerous clinical and experimental data link various Vitamin D-related dysfunctions to epilepsy. Here, we study the role of Vitamin D receptors (VDRs) in experimental epilepsy in mice. To examine this problem, we assessed the seizure profiles in VDR knockout mice following a systemic injection of pentylenetetrazole (70 mg/kg). Overall, compared to the wild-type (WT) 129S1 mice (n = 10 in each group), the VDR knockout group significantly demonstrated shorter latencies to the onset, higher Racine scores and increased mortality rates. Our findings suggest that VDRs modulate seizure susceptibility in mice, and that the Vitamin D/VDR endocrine system may be involved in the pathogenesis of epilepsy.

KW - Chemically induced seizures

KW - Epilepsy

KW - Knockout mice

KW - Vitamin D

KW - Vitamin D receptors

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Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene

Abstract

Keywords

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